Contribution of the Vertebral Posterior Elements in Anterior-Posterior DXA Spine Scans in Young Subjects
Contribution of the Vertebral Posterior Elements in Anterior-Posterior DXA Spine Scans in Young Subjects
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DOI：
10.1359/jbmr.090224
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发表时间：
2009-08-01
影响因子：
6.2
通讯作者：
Wren, Tishya A. L.
中科院分区：
文献类型：
--
作者：
Lee, David C.;Campbell, Patricia P.;Wren, Tishya A. L.
由于DXA是一种投影技术，因此脊柱的前后（AP）测量包括后部元件和椎体。这可能是一个缺点，因为后部元件可能对椎骨骨折抵抗力贡献很小。本研究使用QCT量化DXA AP脊柱测量中后部元素的影响。我们检查了574名受试者（294名女性和280名男性），年龄6-25岁，DXA和QCT。计算松质骨区域和椎体（包括和不包括后部元件）的QCT测量值。对整个L-3椎骨和对应于QCT扫描区域的10 mm切片进行DXA数据分析。测定BMC和BMD，并使用Pearson相关性进行比较。后部成分占总BMC的51.4 +/- 4.2%，男性（49.9 +/- 4.0%）和女性（52.8 +/-3.9%，p < 0.001）之间存在显著差异。在年轻的男女受试者中，这一百分比随着年龄的增长而增加（p < 0.001）。但在17岁以后男性和16岁以后女性相对一致（p > 0.10）。DXA面积] BMD和QCT体积BMD对于整个椎骨（包括后部元件）具有强相关性（R = 0.83），BMC测量显示出更强的相关性（R = 0.93）。当排除后验元素时，关系较弱。我们的结论是，DXA BMC提供了一个衡量骨是最一致的QCT和后元素的贡献是一致的，在性成熟后的年轻受试者。骨矿研究杂志2009;24：1398-.1403。在线发表于2009年2月16日; doi：10.1359/JBMR.090224
Because DXA is a projection technique, anterior-posterior (AP) measurements of the spine include the posterior elements and the vertebral body. This may be a disadvantage because the posterior elements likely contribute little to vertebral fracture resistance. This study used QCT to quantify the impact of the posterior elements in DXA AP spine measures. We examined 574 subjects (294 females and 280 males), age 6-25 yr, with DXA and QCT. QCT measures were calculated for the cancellous bone region and for the vertebral body including and excluding the posterior elements. DXA data were analyzed for the entire L-3 vertebra and for a 10-mm slice corresponding to the QCT scan region. BMC and BMD were determined and compared using Pearson's correlation. The posterior elements accounted for 51.4 +/- 4.2% of the total BMC, with a significant difference between males (49.9 +/- 4.0%) and females (52.8 +/- 3.9%, p < 0.001). This percentage increased with age in younger subjects of both sexes (p < 0.001.) but was relatively consistent after age 17 for males and 16 for females (p > 0.10). DXA area] BMD and QCT volumetric BMD correlated strongly for the whole vertebra including the posterior elements (R = 0.83), with BMC measures showing a stronger relationship (R = 0.93). Relationships were weaker when excluding the posterior elements. We conclude that DXA BMC provides a measure of bone that is most consistent with QCT and that the contribution of the posterior elements is consistent in young subjects after sexual maturity. J Bone Miner Res 2009;24:1398-.1403. Published online on February 16, 2009; doi: 10.1359/JBMR.090224