A formal total synthesis of taxol aided by an automated synthesizer
A formal total synthesis of taxol aided by an automated synthesizer
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DOI：
10.1002/asia.200600156
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发表时间：
2006-09-01
影响因子：
4.1
通讯作者：
Takahashi, Takashi
中科院分区：
文献类型：
--
作者：
Doi, Takayuki;Fuse, Shinichiro;Takahashi, Takashi
在自动合成机上进行了36步合成，得到了紫杉醇的合成关键中间体。微波辅助烷基化反应是由AC前驱体构建ABC环体系的关键步骤。随后形成的D环提供了一种众所周知的紫杉醇前体——巴卡汀III。
A 36-step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave-assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D ring afforded baccatin III, a well-known precursor of taxol.