Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients.
Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients.
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不限盐减肥对超重高血压患者血压降低的影响。
DOI：
10.1056/nejm197801052980101
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
B. Modan
中科院分区：
文献类型：
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作者：
E. Reisin;R. Abel;M. Modan;D. Silverberg;H. Eliahou;B. Modan
超重的无并发症的原发性高血压患者每两周随访一次，为期6个月：24例未接受抗高血压药物治疗（组I）和83例常规但不充分（尽管药物操作）的抗高血压药物治疗（组II）。组I中的所有患者和组II（IIa）中随机选择的57名患者参加了减肥计划。其余26名来自第II组（IIb），没有接受饮食计划。所有三组的盐摄入量均在正常范围内。所有接受饮食计划的患者体重至少减轻了3公斤（平均10.5公斤），除两名患者外，所有患者的血压都有明显下降; 75%的I组患者和61%的IIa组患者血压恢复正常。体重和血压的降低非常显著（P <0.001），在男女和所有年龄段都存在，并且直接相关。在IIb组中，血压或体重没有发生显著变化（P> 0.30）。
Overweight patients with uncomplicated essential hypertension were followed up biweekly for six months: 24 not receiving antihypertensive-drug therapy (Group I) and 83 on regular but inadequate (despite drug manipulation) antihypertensive-drug therapy (Group II). All patients in Group I and 57 randomly selected patients from group II (IIa) participated in a weight-reduction program. The remaining 26 from Group II (IIb) did not receive a dietary program. Salt intake was in the normal range in all three groups. All patients on the dietary program lost at least 3 kg (mean, 10.5 kg), and all but two showed a meaningful reduction in blood pressure; 75 per cent of Group I and 61 per cent of Group IIa returned to normal blood pressure. The weight and blood-pressure reductions were highly significant (P less than 0.001), were present in both sexes and all ages, and were directly associated. In Group IIb, no significant change in blood pressure or weight occurred (P greater than 0.30).