Age-specific prevalence of TB infection among household contacts of pulmonary TB: Is it time for TB preventive therapy?
Age-specific prevalence of TB infection among household contacts of pulmonary TB: Is it time for TB preventive therapy?
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DOI：
10.1093/trstmh/trz049
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发表时间：
2019-10-01
影响因子：
2.2
通讯作者：
Gupta, Amita
中科院分区：
文献类型：
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作者：
Dolla, Chandra Kumar;Padmapriyadarsini, Chandrasekaran;Gupta, Amita
背景：结核病患者的家庭接触者 (HHC) 有很高的风险出现潜伏性结核感染 (LTBI) 和指示患者的活动性疾病证据。我们估计了活动性结核病患者 HHC 中 LTBI 的年龄特异性患病率和感染力 (FI)，作为近期传播的衡量标准。 方法：在印度的两个地点对参与前瞻性研究“CTRIUMPh”的肺结核患者的 HHC 进行横断面分析。 LTBI 定义为结核菌素皮试阳性（硬结 >= 5 mm）或管内 QuantiFERON-Gold 测试（值 >= 0.35 IU/ml），并按年龄分层。 FI 是近期感染传播的衡量标准，通过特定年龄的特定年龄患病率的变化来计算。通过逻辑回归模型确定与 LTBI 相关的因素。 结果：在 441 名成人肺结核病例的 1020 名 HHC 中，有 566 名（55%）女性和 289 名（28%）儿童
Background: Household contacts (HHCs) of TB patients are at high risk of developing evidence of latent TB infection (LTBI) and active disease from the index patient. We estimated the age-specific prevalence of LTBI and the force of infection (FI), as a measure of recent transmission, among HHCs of active TB patients.Methods: A cross-sectional analysis of HHCs of pulmonary TB patients enrolled in a prospective study, 'CTRIUMPh', was conducted at two sites in India. LTBI was defined as either a positive tuberculin skin test (induration >= 5 mm) or QuantiFERON-Gold in tube test (value >= 0.35 IU/ml) and was stratified by age. FI, which is a measure of recent transmission of infection and calculated using changes in age-specific prevalence rates at specific ages, was calculated. Factors associated with LTBI were determined by logistic regression models.Results: Of 1020 HHCs of 441 adult pulmonary TB cases, there were 566 (55%) females and 289 (28%) children aged