MEASUREMENT OF CAROTID-BODY BLOOD-FLOW IN CATS BY USE OF RADIOACTIVE MICROSPHERES
MEASUREMENT OF CAROTID-BODY BLOOD-FLOW IN CATS BY USE OF RADIOACTIVE MICROSPHERES
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DOI：
10.1152/jappl.1988.65.6.2484
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发表时间：
1988-12-01
影响因子：
3.3
通讯作者：
LAHIRI, S
中科院分区：
文献类型：
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作者：
BARNETT, S;MULLIGAN, E;LAHIRI, S
为了解决有关颈动脉体血流量的争议，我们使用放射性微球技术测定组织血流量。我们还测量了猫的其他几个组织的血流量。对13只麻醉、麻痹和机械通气的猫进行了血流量实验。通过导管将不同数量的不同标记的9-、15-和25-μ m微球注射到左心房中。确定了一次注射5 × 104的量。106 15 μ m微球适合于测定颈动脉体血流量。通过使用该方案，向颈动脉体和其他器官的流动如下（ml. min-1. 100 g-1，平均值±。SE）：颈动脉体，1，417. ±.肾上腺，406。89;左肾，355 . ±. 69;右肾，375。74;心脏，201。39;肝脏81。14;胰腺，80。+-。上级颈神经节，62 ±。9;颈动脉壁，2.4 . ±. 1.1.颈动脉体的血流量是所有器官中最高的。这一测量结果提供了新的证据，表明组织血流量的颈动脉体是非常高的。这种高流量与颈动脉体的即时生理反射功能一致。
To resolve the controversy regarding carotid body blood flow, we used the radioactive microsphere technique for determination of tissue blood flow. We also measured the blood flow to several other tissues in the cat. Blood flow experiments were performed on 13 cats that were anesthetized, paralyzed, and mechanically ventilated with air. Different numbers of differently labeled 9-, 15-, and 25-.mu.m microspheres were injected via a catheter into the left atrium. It was determined that one injection of 5 .times. 106 15-.mu.m microspheres was appropriate for the determination of carotid body blood flow. Flows to the carotid bodies and other organs by use of this protocol were as follows (ml .cntdot. min-1 .cntdot. 100 g-1, means .+-. SE): carotid bodies, 1,417 .+-. 143; adrenal glands, 406 .+-. 89; left kidney, 355 .+-. 69; right kidney, 375 .+-. 74; heart, 201 .+-. 39; liver 81 .+-. 14; pancreas, 80 .+-. 21; superior cervical ganglia, 62 .+-. 9; carotid artery wall, 2.4 .+-. 1.1. The blood flow to the carotid bodies was the highest for any organ. This measurement provides new evidence that tissue blood flow to the carotid body is very high. This high flow is consistent with the prompt physiological reflex functions of the carotid body.