Association of right ventricular dysfunction and pulmonary hypertension with adverse 30-day outcomes in COVID-19 patients.
Association of right ventricular dysfunction and pulmonary hypertension with adverse 30-day outcomes in COVID-19 patients.
复制标题
右心室功能障碍和肺动脉高压与190例患者的30天结局的关联。
DOI：
10.1177/20458940211007040
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发表时间：
2021-04
影响因子：
2.6
通讯作者：
Jacob J
中科院分区：
文献类型：
--
作者：
Wats K;Rodriguez D;Prins KW;Sadiq A;Fogel J;Goldberger M;Moskovits M;Tootkaboni MP;Shani J;Jacob J
Cardiac manifestations in COVID-19 are multifactorial and are associated with increased mortality. The clinical utility and prognostic value of echocardiography in COVID-19 inpatients is not clearly defined. We aim to identify echocardiographic parameters that are associated with 30-day clinical outcomes secondary to COVID-19 hospitalization. This retrospective cohort study was conducted in a large tertiary hospital in New York City during the COVID-19 pandemic. It included 214 adult inpatients with a laboratory-confirmed diagnosis of COVID-19 by reverse transcriptase polymerase chain reaction assay (RT-PCR) for SARS-CoV-2 on nasopharyngeal swab and had a transthoracic echocardiogram performed during the index hospitalization. Primary outcome was 30-day all-cause inpatient mortality. Secondary outcomes were 30-day utilization of mechanical ventilator support, vasopressors, or renal replacement therapy. Mild right ventricular systolic dysfunction (odds ratio (OR): 3.51, 95% confidence interval (CI): 1.63–7.57, p = 0.001), moderate to severe right ventricular systolic dysfunction (OR: 7.30, 95% CI: 2.20–24.25, p = 0.001), pulmonary hypertension (OR: 5.39, 95% CI: 1.96–14.86, p = 0.001), and moderate to severe tricuspid regurgitation (OR: 3.92, 95% CI: 1.71–9.03, p = 0.001) were each associated with increased odds of 30-day all-cause inpatient mortality. Pulmonary hypertension and moderate to severe right ventricular dysfunction were each associated with increased odds of 30-day utilization of mechanical ventilator support and vasopressors. Right ventricular dysfunction, pulmonary hypertension, and moderate to severe tricuspid regurgitation were associated with increased odds for 30-day inpatient mortality. This study highlights the importance of echocardiography and its clinical utility and prognostic value for evaluating hospitalized COVID-19 patients.
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影响因子：
6.2
作者：
Lang, Roberto M.;Badano, Luigi P.;Voigt, Jens-Uwe
通讯作者：
Voigt, Jens-Uwe
影响因子：
38.9
作者：
Boissier, Florence;Katsahian, Sandrine;Dessap, Armand Mekontso
通讯作者：
Dessap, Armand Mekontso
影响因子：
158.5
作者：
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通讯作者：
Jonigk, Danny
DOI：
10.1016/j.healun.2017.08.011
发表时间：
2018-03
期刊：
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
影响因子：
--
作者：
Prins KW;Archer SL;Pritzker M;Rose L;Weir EK;Sharma A;Thenappan T
通讯作者：
Thenappan T
影响因子：
24
作者：
Damman, Kevin;van Deursen, Vincent M.;Hillege, Hans L.
通讯作者：
Hillege, Hans L.