Abnormal reactivity of the ∼20-Hz motor cortex rhythm in Unverricht Lundborg type progressive myoclonus epilepsy
Abnormal reactivity of the ∼20-Hz motor cortex rhythm in Unverricht Lundborg type progressive myoclonus epilepsy
复制标题
DOI：
10.1006/nimg.2000.0660
复制
发表时间：
2000-12-01
期刊：
影响因子：
5.7
通讯作者：
Hari, R
中科院分区：
文献类型：
--
作者：
Silén, T;Forss, N;Hari, R
我们用全头皮神经磁力计监测了7例Unverricht-Lundborg型（ULD）进行性肌阵挛癫痫（PME）患者和7例健康对照者的20 Hz节律反应性，并将其作为反映初级运动皮层功能状态的指标。在患者中，运动皮层节律的频率平均低5 Hz，其强度是对照组的两倍。为了研究类似于20 Hz节律的反应性，在手腕处交替刺激左右正中神经。在对照组中，这些刺激引起了一个小的短暂的减少，随后是一个强烈的增加（“反弹”）的类似20赫兹的水平。相反，患者没有表现出明显的心律反弹。由于类似于20 Hz的反弹显然反映了皮层抑制的增加，我们的研究结果表明，外周刺激兴奋运动皮层长时间在ULD患者。(C)北京大学出版社.
The similar to 20-Hz component of the human mu rhythm originates predominantly in the primary motor cortex, We monitored with a whole-scalp neuromagnetometer the reactivity of the similar to 20-Hz rhythm as an index of the functional state of the primary motor cortex in seven patients suffering from Unverricht-Lundborg type (ULD) progressive myoclonus epilepsy (PME) and in seven healthy control subjects. In patients, the motor cortex rhythm was on average 5 Hz lower in frequency and its strength was double compared with controls. To study reactivity of the similar to 20-Hz rhythm, left and right median nerves were stimulated alternately at wrists. In controls, these stimuli elicited a small transient decrease, followed by a strong increase ("rebound") of the similar to 20-Hz level. In contrast, the patients showed no significant rebounds of the rhythm. As the similar to 20-Hz rebounds apparently reflect increased cortical inhibition, our results indicate that peripheral stimuli excite motor cortex for prolonged periods in patients with ULD. (C) 2000 Academic Press.