Phasic discharge of antidromically identified units in the paraventricular nucleus of the hypothalamus.
Phasic discharge of antidromically identified units in the paraventricular nucleus of the hypothalamus.
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下丘脑室旁核中逆向识别单位的阶段性放电。
DOI：
10.1016/0006-8993(71)90580-4
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发表时间：
1971
期刊：
影响因子：
2.9
通讯作者：
D. Lincoln
中科院分区：
文献类型：
--
作者：
J. B. Wakerley;D. Lincoln
图二.显示阶段性活动的逆向识别肺静脉单位的测谎记录。脑电图记录同时从额叶皮层。这两条轨迹是连续的。研究下丘脑的邻近部分。在PV核的组织学边界外没有发现逆向激活的单位，尽管核内的几个单位即使在上面和下面的单位也没有被激活。逆向峰电位的平均潜伏期为12.1 msec（范围7-26 msec），阈值电流范围为500 ffA至5 mA。PV和邻近下丘脑单位的平均放电率分别为2.2和3.5峰/秒。然而，在这两种情况下，放电率分布的泊松曲线的形式，与一个大比例的单位显示没有自发活动。18%的逆行性识别的PV单位显示出阶段性放电，其特征在于交替的沉默期（“关闭”阶段）和活动期（“开启”阶段）（图1和2）。这些相位突然改变，与皮层EEG没有相关性（图2）。“开”相的平均持续时间为30.3秒（范围8.0 - 95.6秒），“关”相的持续时间为22.9秒（范围11.2-50.4秒）。因此，平均循环时间为53.2秒。然而，对于任何一只动物，每个阶段的时间都相对恒定。阶段性单位比其他PV单位更活跃，在“上”阶段，并在5.0尖峰/秒（范围2.4 - 7.5/秒）发射。几个阶段单位记录超过1小时的时间，在整个这段时间内，他们的活动模式保持不变。在发情周期的每个阶段的记录中发现的阶段性放电模式。虽然在PV核内和周围的许多非激活单位的放电率都发生了变化，但这些变化从来都不是戏剧性的，并且总是与额叶皮层的EEG模式相关。这些装置从未遇到过相性活动。
Fig. 2. Polygraph record of an antidromicatly identified PV unit showing phasic activity. The EEG was recorded simultaneously from the frontal cortex. The two traces are continuous. adjacent parts of the hypothalamus were studied. No antidromically activated units were found outside the histological boundary of the PV nucleus, though several units within the nucleus were not activated even when those above and below gave a positive response. The mean latency of the antidromic spike was 12.1 msec (range 7-26 msec), and the threshold current ranged from 500 ffA to 5 mA. The mean firing rates of PV and adjacent hypothalamic units were 2.2 and 3.5 spikes/sec, respectively. In both cases, however, the firing rates were distributed in the form of Poisson curves, with a large proportion of the units showing no spontaneous activity. Eighteen percent of the antidromically identified PV units displayed a phasic discharge which was characterized by alternate periods of silence ('off'phase) and activity ('on'phase)(Figs. 1 and 2), These phases changed abruptly and there was no correlation with the cortical EEG (Fig. 2). The'on'phases had a mean duration of 30.3 sec (range 8.0 95.6 sec) and the'off'phases had a duration of 22.9 sec (range 11.2-50.4 sec). The mean cycle time was therefore 53.2 sec. For any one animal, however, the times of each phase were relatively constant. The phasic units were more active than other PV units during the'on'phase and fired at 5.0 spikes/sec (range 2.4 7.5/sec). Several of the phasic units were recorded for periods in excess of 1 h and throughout this time their pattern of activity remained unchanged. The phasic pattern of discharge was found in recordings taken at each stage of the oestrous cycle. Although changes were seen in the firing rates of many non-activated units, both in and around the PV nucleus, these changes were never dramatic and were invariably correlated with the EEG pattern of the frontal cortex. Phasic activity was never encountered with these units.