TRANSFORMATION OF BIPHASIC CALCIUM-PHOSPHATE CERAMICS INVIVO - ULTRASTRUCTURAL AND PHYSICOCHEMICAL CHARACTERIZATION
TRANSFORMATION OF BIPHASIC CALCIUM-PHOSPHATE CERAMICS INVIVO - ULTRASTRUCTURAL AND PHYSICOCHEMICAL CHARACTERIZATION
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DOI：
10.1002/jbm.820230806
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发表时间：
1989-08-01
期刊：
影响因子：
--
通讯作者：
KEREBEL, B
中科院分区：
文献类型：
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作者：
DACULSI, G;LEGEROS, RZ;KEREBEL, B
特殊制备的双相磷酸钙 (BCP) 大孔陶瓷由 β 磷酸三钙 (b̃-TCP) 和羟基磷灰石 (HA) 紧密结合组成，b̃-TCP/HA 重量比为 15/85、35/65 和 85/15，被植入狗手术造成的牙周骨缺损中，并在 6 年后恢复。 几个月。植入后观察到 BCP 陶瓷中晶体平均尺寸的减小以及陶瓷表面和核心微孔尺寸的增加，表明发生了体内溶解。 BCP陶瓷的再吸收性（反映体内溶解度）取决于它们的b̃-TCP/HA比率，比率越高，再吸收性越大。还观察到具有与骨磷灰石晶体相似的晶体学性质和Ca/P比的微晶体的形成。这些晶体的丰度与植入前 BCP 陶瓷的 b̃-TCP/HA 比率直接相关。骨磷灰石晶体的形成可能是由于溶解的陶瓷晶体中释放出钙离子和磷酸根离子的沉淀（b̃-TCP 组分优先于 HA 组分溶解）。这项研究的结果表明，控制 BCP 陶瓷的再吸收性（体内溶解）的方法之一是改变其 b̃-TCP/HA 比率。
Specially prepared biphasic calcium phosphate (BCP) macroporous ceramics consisting of an intimate association of beta tricalcium phosphate (b̃‐TCP) and hydroxyapatite (HA) with b̃‐TCP/HA weight ratios of 15/85, 35/65, and 85/15 were implanted in surgically created periodontal osseous defects in dogs and recovered after 6 months. A decrease in average size of crystals in BCP ceramics and an increase in the size of microporosities in the surface and at the core of the ceramic after implantation were observed, indicating thatin vivodissolution has taken place. The resorbability (reflectingin vivodissolution) of BCP ceramics depended on their b̃‐TCP/HA ratios, the higher the ratio, the greater the resorbability. The formation of microcrystals with crystallographic properties and Ca/P ratio similar to those of bone apatite crystals were also observed. The abundance of these crystals were directly related to the b̃‐TCP/HA ratio of the BCP ceramic before implantation. The formation of the bone apatite‐like crystals may be due to the precipitation of calcium and phosphate ions released from the dissolving ceramic crystals (the b̃‐TCP component dissolving preferentially to the HA component). Results from this study suggested that one of the means of controlling resorbability (in vivodissolution) of BCP ceramic is by varying its b̃‐TCP/HA ratio.