The immune modulating properties of the heat shock proteins after brain injury.
The immune modulating properties of the heat shock proteins after brain injury.
复制标题
DOI：
10.5115/acb.2013.46.1.1
复制
发表时间：
2013-03
影响因子：
1.1
通讯作者：
Yenari MA
中科院分区：
文献类型：
--
作者：
Kim JY;Yenari MA
中枢神经系统内的炎症通常伴随着缺血、创伤、感染和其他神经元损伤。现在人们认识到免疫系统在小胶质细胞激活、白细胞募集和细胞因子分泌导致的神经细胞死亡中发挥着重要作用。热休克蛋白（Hsps）参与脑损伤后的免疫反应可以被视为纠正炎症状况的尝试。 Hsps 根据分子大小由不同的家族组成。研究最多的之一是 Hsp70。 Hsp70 被认为充当分子伴侣，几乎存在于细胞内区室中，并通过重新折叠错误折叠或聚集的蛋白质发挥作用。最近在炎症条件下研究了热休克蛋白。 Hsp70 可以诱导和抑制炎症反应，并改善实验性脑损伤和缺血的神经系统结果。在这篇综述中，我们将重点关注急性神经损伤中的潜在炎症机制和 Hsp70。
Inflammation within the central nervous system often accompanies ischemia, trauma, infection, and other neuronal injuries. The immune system is now recognized to play a major role in neuronal cell death due to microglial activation, leukocyte recruitment, and cytokine secretion. The participation of heat shock proteins (Hsps) in the immune response following in brain injury can be seen as an attempt to correct the inflammatory condition. The Hsps comprise various families on the basis of molecular size. One of the most studied is Hsp70. Hsp70 is thought to act as a molecular chaperone that is present in almost intracellular compartments, and function by refolding misfolded or aggregated proteins. Hsps have recently been studied in inflammatory conditions. Hsp70 can both induce and arrest inflammatory reactions and lead to improved neurological outcome in experimental brain injury and ischemia. In this review, we will focus on underlying inflammatory mechanisms and Hsp70 in acute neurological injury.