Renal function‐dependent association of serum uric acid with metabolic syndrome and hepatic fat content in a middle‐aged and elderly Chinese population
Renal function‐dependent association of serum uric acid with metabolic syndrome and hepatic fat content in a middle‐aged and elderly Chinese population
复制标题
DOI：
10.1111/1440-1681.12011
复制
发表时间：
2012-11
影响因子：
2.9
通讯作者：
Mingfeng Xia;Huan-Dong Lin;Xiao-ming Li;Hongmei Yan;H. Bian;Xin-xia Chang;Wan-yuan He;J. Jeekel;A. Hofman;Xin Gao
中科院分区：
文献类型：
--
作者：
Mingfeng Xia;Huan-Dong Lin;Xiao-ming Li;Hongmei Yan;H. Bian;Xin-xia Chang;Wan-yuan He;J. Jeekel;A. Hofman;Xin Gao
尿酸（UA）在代谢紊乱的发病机制中的作用高度依赖于其理化性质，不同情况下的高尿酸血症可能具有不同的临床意义。本研究的目的是在肾功能正常和受损的中老年人群中研究血清UA水平与代谢综合征和非酒精性脂肪性肝病（NAFLD）的相关性。这项横断面研究对1141名参与者（426名男性，715名女性;平均年龄62岁）进行，这些参与者来自上海长风社区。每个参与者都接受了标准的采访，人体测量和实验室测量。肝脂肪含量（HFC）测定采用新建立的定量超声方法。单因素相关分析显示，UA与代谢综合征各组分及HFC均相关（r = 0.193，P < 0.001），尤其是在肾小球滤过率（eGFR; r = 0.255，P < 0.001）正常的受试者中。Logistic回归分析显示，在肾功能正常的参与者中，血清UA与代谢综合征和NAFLD独立相关，但在eGFR < 90 mL/min/1.73 m2的参与者中不相关。此外，多变量线性分析显示UA水平与HFC独立相关（P = 0.003），但仅在eGFR正常的参与者中。在肾排泄功能正常的患者中，血清UA升高与代谢综合征和NAFLD独立相关。然而，在肾功能不全患者中，高尿酸血症与代谢紊乱无关。
The effect of uric acid (UA) on the pathogenesis of metabolic disorders is highly dependent on its physicochemical properties, and hyperuricaemia associated with different conditions may have different clinical meanings. The aim of the present study was to investigate the association of serum UA levels with metabolic syndrome and non‐alcoholic fatty liver disease (NAFLD) in a middle‐aged and elderly population with normal and impaired renal function. The cross‐sectional study was performed on 1141 participants (426 men, 715 women; mean age 62 years) enrolled from the Shanghai Changfeng community. Each participant underwent a standard interview, with anthropometric and laboratory measurements. Hepatic fat content (HFC) was determined by a newly established quantitative ultrasound method. Univariate correlation analysis showed that serum UA was associated with all components of metabolic syndrome and HFC (r = 0.193, P < 0.001), especially in participants with a normal estimated glomerular filtration rate (eGFR; r = 0.255, P < 0.001). Logistic regression analysis demonstrated an independent association of serum UA with metabolic syndrome and NAFLD in participants with normal renal function, but not in those with eGFR < 90 mL/min per 1.73 m2. Furthermore, multivariate linear analysis showed that UA levels were independently associated with HFC (P = 0.003), but only in participants with normal eGFR. Elevated serum UA is independently associated with metabolic syndrome and NAFLD in patients with normal renal excretory function. However, in those with renal insufficiency, hyperuricaemia has no association with metabolic disorders.