Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo.
Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo.
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DOI：
10.4049/jimmunol.180.4.2538
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发表时间：
2008-02-15
影响因子：
4.4
通讯作者：
Vanhaesebroeck, Bart
中科院分区：
文献类型：
--
作者：
Ali, Khaled;Camps, Montserrat;Pearce, Wayne P.;Ji, Hong;Rueckle, Thomas;Kuehn, Nicolas;Pasquali, Christian;Chabert, Christian;Rommel, Christian;Vanhaesebroeck, Bart
The leukocyte-enriched p110γ and p110δ isoforms of PI3K have been shown to control in vitro degranulation of mast cells induced by cross-linking of the high affinity receptor of IgE (FcεRI). However, the relative contribution of these PI3K isoforms in IgE-dependent allergic responses in vivo is controversial. A side-by-side comparative analysis of the role of p110γ and p110δ in mast cell function, using genetic approaches and newly developed isoform-selective pharmacologic inhibitors, confirms that both PI3K isoforms play an important role in FcεRI-activated mast cell degranulation in vitro. In vivo, however, only p110δ was found to be required for optimal IgE/Ag-dependent hypersensitivity responses in mice. These observations identify p110δ as a key therapeutic target among PI3K isoforms for allergy- and mast cell-related diseases.
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通讯作者：
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影响因子：
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