Effect of Associated Autoimmune Diseases on Type 1 Diabetes Mellitus Incidence and Metabolic Control in Children and Adolescents.
Effect of Associated Autoimmune Diseases on Type 1 Diabetes Mellitus Incidence and Metabolic Control in Children and Adolescents.
复制标题
相关自身免疫性疾病对儿童和青少年的1型糖尿病发生率和代谢控制的影响。
DOI：
10.1155/2016/6219730
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发表时间：
2016
影响因子：
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通讯作者：
Ben-Skowronek I
中科院分区：
文献类型：
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作者：
Krzewska A;Ben-Skowronek I
1型糖尿病（T1 DM）是儿童期最常见的慢性疾病之一。在世界范围内，儿童的发病率每年以3%至5%的速度增长，原因不明。T1 DM的背景与胰腺β细胞破坏的自身免疫过程相关，这导致绝对胰岛素缺乏和器官损伤。环境和遗传因素之间的复杂相互作用有助于遗传易感患者发生T1 DM。T1 DM诱导的自身免疫过程也会影响其他器官，导致患者发生其他自身免疫疾病，从而阻碍糖尿病控制。最常见的T1 DM合并症包括自身免疫性甲状腺疾病、乳糜泻和自身免疫性胃炎;此外，糖尿病可能是PAS（多腺体自身免疫综合征）的组成部分。本综述的目的是评估儿童和青少年T1 DM相关自身免疫性疾病的患病率及其对T1 DM病程的影响。我们还提出了有关筛选测试的建议。
Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases developing in childhood. The incidence of the disease in children increases for unknown reasons at a rate from 3 to 5% every year worldwide. The background of T1DM is associated with the autoimmune process of pancreatic beta cell destruction, which leads to absolute insulin deficiency and organ damage. Complex interactions between environmental and genetic factors contribute to the development of T1DM in genetically predisposed patients. The T1DM-inducing autoimmune process can also affect other organs, resulting in development of additional autoimmune diseases in the patient, thereby impeding diabetes control. The most common T1DM comorbidities include autoimmune thyroid diseases, celiac disease, and autoimmune gastritis; additionally, diabetes can be a component of PAS (Polyglandular Autoimmune Syndrome). The aim of this review is to assess the prevalence of T1DM-associated autoimmune diseases in children and adolescents and their impact on the course of T1DM. We also present suggestions concerning screening tests.