Heparan sulfate proteoglycans: coordinators of multiple signaling pathways during chondrogenesis.
Heparan sulfate proteoglycans: coordinators of multiple signaling pathways during chondrogenesis.
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DOI：
10.1002/bdrc.20005
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发表时间：
2004-03-01
期刊：
影响因子：
--
通讯作者：
Carson, Daniel D
中科院分区：
文献类型：
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作者：
Kirn-Safran, Catherine B;Gomes, Ronald R;Carson, Daniel D
硫酸乙酰肝素蛋白聚糖在发育和成熟软骨的细胞周围基质中大量表达。越来越多的证据表明，许多软骨调节分子的行动取决于这些蛋白多糖。本文综述了软骨蛋白多糖硫酸乙酰肝素链在软骨形成过程中与可溶性和非可溶性配体的相互作用。此外，突变基因编码硫酸乙酰肝素生物合成酶或硫酸乙酰肝素蛋白聚糖核心蛋白对软骨发育的后果进行了讨论。
Heparan sulfate proteoglycans are abundantly expressed in the pericellular matrix of both developing and mature cartilage. Increasing evidence indicates that the action of numerous chondroregulatory molecules depends on these proteoglycans. This review summarizes the current understanding of the interactions of heparan sulfate chains of cartilage proteoglycans with both soluble and nonsoluble ligands during the process of chondrogenesis. In addition, the consequences of mutating genes encoding heparan sulfate biosynthetic enzymes or heparan sulfate proteoglycan core proteins on cartilage development are discussed.