Hematopoietic Stem Cells in Wound Healing Response.
Hematopoietic Stem Cells in Wound Healing Response.
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DOI：
10.1089/wound.2021.0065
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发表时间：
2022-11
影响因子：
4.9
通讯作者：
Ganesh, Gayathri
中科院分区：
文献类型：
--
作者：
Urao, Norifumi;Liu, Jinghua;Takahashi, Kentaro;Ganesh, Gayathri
新出现的证据表明造血干细胞（HSC）的状态与伤口愈合反应之间存在联系。因此，更好地了解HSC将有助于伤口愈合研究的进一步进展。骨髓细胞如中性粒细胞和单核细胞衍生的巨噬细胞是伤口愈合过程中的关键参与者。HSC积极响应伤口损伤和其他组织损伤，包括感染，并产生效应骨髓细胞，HSC响应的失败可导致伤口愈合受损。诸如单细胞分辨率的转录组、表观遗传学、三维成像、转基因动物和动物模型的技术进步提供了从HSC产生骨髓（骨髓生成）的新概念，并且揭示了可以在健康状况的背景下影响HSC功能的细胞内在和外在机制。较新的概念包括：分化阶段的程序化细胞命运（常被认为是多谱系）、直接或间接激活HSC的信号通路、HSC退化的机制、HSC及其祖细胞周围环境的作用和重塑（生态位）。对产生血细胞的HSC的研究应该有助于开发预测慢性伤口风险的血液生物标志物，这可能会改变伤口护理的临床实践，为高风险的患者提供精确的医疗。
Emerging evidence has shown a link between the status of hematopoietic stem cells (HSCs) and wound healing responses. Thus, better understanding HSCs will contribute to further advances in wound healing research. Myeloid cells such as neutrophils and monocyte-derived macrophages are critical players in the process of wound healing. HSCs actively respond to wound injury and other tissue insults, including infection and produce the effector myeloid cells, and a failing of the HSC response can result in impaired wound healing. Technological advances such as transcriptome at single-cell resolution, epigenetics, three-dimensional imaging, transgenic animals, and animal models, have provided novel concepts of myeloid generation (myelopoiesis) from HSCs, and have revealed cell-intrinsic and -extrinsic mechanisms that can impact HSC functions in the context of health conditions. The newer concepts include—the programmed cellular fate at a differentiation stage that is used to be considered as the multilineage, the signaling pathways that can activate HSCs directly and indirectly, the mechanisms that can deteriorate HSCs, the roles and remodeling of the surrounding environment for HSCs and their progenitors (the niche). The researches on HSCs, which produce blood cells, should contribute to the development of blood biomarkers predicting a risk of chronic wounds, which may transform clinical practice of wound care with precision medicine for patients at high risk of poor healing.
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影响因子：
20.1
作者：
Barcelos LS;Duplaa C;Kränkel N;Graiani G;Invernici G;Katare R;Siragusa M;Meloni M;Campesi I;Monica M;Simm A;Campagnolo P;Mangialardi G;Stevanato L;Alessandri G;Emanueli C;Madeddu P
通讯作者：
Madeddu P
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
64.8
作者：
Busch, Katrin;Klapproth, Kay;Rodewald, Hans-Reimer
通讯作者：
Rodewald, Hans-Reimer
慢性交感神经驱动的高血压通过增强造血作用促进动脉粥样硬化。
影响因子：
10.1
作者：
Al-Sharea A;Lee MKS;Whillas A;Michell DL;Shihata WA;Nicholls AJ;Cooney OD;Kraakman MJ;Veiga CB;Jefferis AM;Jackson K;Nagareddy PR;Lambert G;Wong CHY;Andrews KL;Head GA;Chin-Dusting J;Murphy AJ
通讯作者：
Murphy AJ
DOI：
10.1084/jem.20102049
发表时间：
2011-03-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bulua AC;Simon A;Maddipati R;Pelletier M;Park H;Kim KY;Sack MN;Kastner DL;Siegel RM
通讯作者：
Siegel RM