CD8+ T cell metabolic changes in breast cancer.
CD8+ T cell metabolic changes in breast cancer.
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DOI：
10.1016/j.bbadis.2022.166565
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发表时间：
2022-10
期刊：
影响因子：
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通讯作者：
Angela Castoldi;Jennifer Lee;Daniel de Siqueira Carvalho;F. Souto
中科院分区：
文献类型：
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作者：
Angela Castoldi;Jennifer Lee;Daniel de Siqueira Carvalho;F. Souto
免疫新陈代谢促进了我们对细胞环境和营养物质如何调节免疫细胞命运的理解。代谢途径不仅与细胞信号和分化密切相关，而且可以诱导不同的免疫细胞亚群采用独特的代谢程序，影响疾病的进展。免疫细胞代谢失调在包括乳腺癌(BC)在内的多种疾病的发展中起着重要作用。代谢重编程在调节T细胞功能中起着关键作用。CD8+T细胞是肿瘤微环境(TME)中必不可少的细胞类型。为了诱导抗肿瘤反应，CD8+T细胞需要调整其代谢来满足其有效功能所需的能量需求。然而，不同的标志物和免疫学技术使得识别BC中特定的CD8+T细胞亚型成为该领域的挑战。这篇综述讨论了在BC的背景下TME中CD8+T细胞的免疫代谢过程，并强调了CD8+T细胞代谢变化在肿瘤进展中的作用。
Immunometabolism has advanced our understanding of how the cellular environment and nutrient availability regulates immune cell fate. Not only are metabolic pathways closely tied to cell signaling and differentiation, but can induce different subsets of immune cells to adopt unique metabolic programs, influencing disease progression. Dysregulation of immune cell metabolism plays an essential role in the progression of several diseases including breast cancer (BC). Metabolic reprogramming plays a critical role in regulating T cell functions. CD8+T cells are an essential cell type within the tumor microenvironment (TME). To induce antitumor responses, CD8+T cells need to adapt their metabolism to fulfill their energy requirement for effective function. However, different markers and immunologic techniques have made identifying specific CD8+T cells subtypes in BC a challenge to the field. This review discusses the immunometabolic processes of CD8+T cell in the TME in the context of BC and highlights the role of CD8+T cell metabolic changes in tumor progression.