Quantitative Paraspinal Muscle Measurements: Inter-Software Reliability and Agreement Using OsiriX and ImageJ
Quantitative Paraspinal Muscle Measurements: Inter-Software Reliability and Agreement Using OsiriX and ImageJ
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DOI：
10.2522/ptj.20110380
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发表时间：
2012-06-01
期刊：
影响因子：
3.2
通讯作者：
Battie, Michele C.
中科院分区：
文献类型：
--
作者：
Fortin, Maryse;Battie, Michele C.
背景资料。椎旁肌横截面积(CSA)和成分的变化，特别是多裂肌的组成，与下腰痛问题的风险和恢复有关。一些研究人员已经使用各种方案和图像分析程序报告了这种肌肉测量的可靠性。然而，目前还没有用于组织分割的标准方案，也没有关于使用不同软件测量的可靠性或一致性的调查。本研究的目的是提供详细的肌肉测量方案，并确定使用两个常用的图像分析程序：OsiriX和ImageJ.Design获得的相关椎旁肌肉成分测量的可靠性和一致性。这是一项测量可靠性研究。30名患者的腰椎磁共振图像是从一组患有各种腰背疾病的患者中随机挑选出来的。每个参与者的肌肉CSA和成分测量来自于L4-L5和S1的多裂肌、竖脊肌和两块肌肉的轴向T2加权磁共振图像。使用每个软件程序重复所有测量两次，间隔至少5天。评价员对之前的所有测量都视而不见。使用OsiriX或ImageJ获得的大多数测量的仪器内可靠性和标准测量误差(SEM)是相似的，可靠性系数(组内相关系数[ICCs])在OsiriX的0.77至0.99和ImageJ的0.78至0.99之间变化。同样，使用两个软件应用程序(软件间ICCS=.81-.99)测量肌肉成分之间也有很好的一致性。软件间测量的高度可靠性可能不会推广到使用其他商业或定制软件的协议。所提出的研究椎旁肌肉CSA、成分和侧对侧不对称的方法是高度可靠的，两个软件程序之间具有很好的一致性。
Background. Variations in paraspinal muscle cross-sectional area (CSA) and composition, particularly of the multifidus muscle, have been of interest with respect to risk of, and recovery from, low back pain problems. Several investigators have reported on the reliability of such muscle measurements using various protocols and image analysis programs. However, there is no standard protocol for tissue segmentation, nor has there been an investigation of reliability or agreement of measurements using different software.Objective. The purpose of this study was to provide a detailed muscle measurement protocol and determine the reliability and agreement of associated paraspinal muscle composition measurements obtained with 2 commonly used image analysis programs: OsiriX and ImageJ.Design. This was a measurement reliability study.Methods. Lumbar magnetic resonance images of 30 individuals were randomly selected from a cohort of patients with various low back conditions. Muscle CSA and Composition measurements were acquired from axial T2-weighted magnetic resonance images of the multifidus muscle, the erector spinae muscle, and the 2 muscles combined at L4 -L5 and S1 for each participant. All measurements were repeated twice using each software program, at least 5 days apart. The assessor was blinded to all earlier measurements.Results. The intrarater reliability and standard error of measurement (SEM) were comparable for most measurements obtained using OsiriX or ImageJ, with reliability coefficients (intraclass correlation coefficients [ICCs]) varying between .77 and .99 for OsiriX and .78 and .99 for ImageJ. There was similarly excellent agreement between muscle composition measurements using the 2 software applications (inter-software ICCs =.81-.99).Limitations. The high degree of inter-software measurement reliability may not generalize to protocols using other commercial or custom-made software.Conclusion. The proposed method to investigate paraspinal muscle CSA, composition, and side-to-side asymmetry was highly reliable, with excellent agreement between the 2 software programs.