Beat-to-beat stroke volume estimation from aortic pressure waveform in conscious rats: comparison of models
Beat-to-beat stroke volume estimation from aortic pressure waveform in conscious rats: comparison of models
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DOI：
10.1152/ajpheart.2001.281.3.h1148
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发表时间：
2001-09-01
影响因子：
4.8
通讯作者：
Paultre, CZ
中科院分区：
文献类型：
--
作者：
Cerutti, C;Gustin, MP;Paultre, CZ
在清醒、自由活动的大鼠中测试了几种估计每搏输出量（SV）的方法，其中同时（逐搏）记录升主动脉压和心脏流量。我们比较了两个脉冲轮廓模型，两个新的统计模型，包括八个参数提取的压力波形在多元线性回归。总体和个体统计模型的估计和测量SV（模型1，r = 0.97;模型2，r = 0.96）之间的相关系数高于脉搏轮廓模型（模型1，r = 0.83;模型2，r = 0.91）。后一种模型以及统计模型1使用脉动收缩面积，因此仅适用于47 +/- 17%的心跳。相反，统计模型2使用压力增加特性，因此针对所有心跳建立。应用于独立于用于建立模型的数据集的全局统计模型2给出了可靠的SV估计值：r = 0.54 +/- 0.07，-8%至+10%之间的小偏差，平均精度为7%。这项工作证明了脉搏轮廓模型的局限性，以估计SV清醒，不受约束的大鼠。一个多变量的统计模型，使用八个参数很容易提取的主动脉波形可以适用于所有的心脏搏动具有良好的精度。
Several methods for estimating stroke volume (SV) were tested in conscious, freely moving rats in which ascending aortic pressure and cardiac flow were simultaneously (beat-to-beat) recorded. We compared two pulse-contour models to two new statistical models including eight parameters extracted from the pressure waveform in a multiple linear regression. Global as well as individual statistical models gave higher correlation coefficients between estimated and measured SV (model 1, r = 0.97; model 2, r = 0.96) than pulse-contour models (model 1, r = 0.83; model 2, r = 0.91). The latter models as well as statistical model 1 used the pulsatile systolic area and thus could be applied to only 47 +/- 17% of the cardiac beats. In contrast, statistical model 2 used the pressure-increase characteristics and was therefore established for all of the cardiac beats. The global statistical model 2 applied to data sets independent of those used to establish the model gave reliable SV estimates: r = 0.54 +/- 0.07, a small bias between -8% to + 10%, and a mean precision of 7%. This work demonstrated the limits of pulse-contour models to estimate SV in conscious, unrestrained rats. A multivariate statistical model using eight parameters easily extracted from the aortic waveform could be applied to all cardiac beats with good precision.