Pd/norbornene-catalyzed sequential ortho -C–H alkylation and ipso -alkynylation: a 1,1-dimethyl-2-alkynol strategy
Pd/norbornene-catalyzed sequential ortho -C–H alkylation and ipso -alkynylation: a 1,1-dimethyl-2-alkynol strategy
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DOI：
10.1039/c5qo00391a
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发表时间：
2016-02
影响因子：
5.4
通讯作者：
Fenggang Sun;Miao Li;Z. Gu
中科院分区：
文献类型：
--
作者：
Fenggang Sun;Miao Li;Z. Gu
报道了钯/降冰片烯催化的邻位C-H烷基化和异位炔基化反应合成2-烷基-1-炔基芳烃。以1，1-二甲基-2-炔醇为炔基试剂时，侧链O-烷基化反应大部分被抑制，三组分的反应活性匹配良好。其结果是，A、B型副产物可以得到很好的抑制，并获得了好的到极好的产率。
A palladium/norbornene-catalyzed ortho-C–H alkylation and ipso-alkynylation reaction for the synthesis of 2-alkyl-1-alkynyl arenes was reported. By the use of 1,1-dimethyl-2-alkynols as alkynyl reagents, the side O-alkylation reaction was mostly inhibited, and the reactivity of the three components matched well. As a result, A- and B-type side-products could be substantially inhibited and good to excellent yields were achieved.