The association between high-sensitivity C-reactive protein and hypertension in women of the CARDIA study
The association between high-sensitivity C-reactive protein and hypertension in women of the CARDIA study
复制标题
DOI：
10.1097/gme.0000000000000609
复制
发表时间：
2016-06-01
期刊：
影响因子：
--
通讯作者：
Wellons, Mellissa
中科院分区：
文献类型：
--
作者：
Ebong, Imo A.;Schreiner, Pamela;Wellons, Mellissa
目的：本研究的目的是确定中年女性高血压的患病率，描述高敏感性c反应蛋白（hs-CRP）与女性高血压之间的关系，并描述绝经期高血压患病率的差异。方法：我们纳入了1625名年龄在43至55岁之间的女性，在随访25年的年轻人冠状动脉风险发展研究中测量了hs-CRP和详细的生殖史。高血压的定义是收缩压为140毫米汞柱，或舒张压为90毫米汞柱或更高，或使用抗高血压药物。采用Logistic回归进行分析。结果：绝经前、围绝经期和绝经后妇女高血压患病率分别为25.8%、37.8%和39.0%。高血压和非高血压女性hs-CRP的中位数（25和75百分位数）分别为3.08 (1.12,7.98)mu g/mL和1.18 (0.48,3.15)mu g/mL。在调整混杂因素、代谢因素和体重指数后，hs-CRP水平翻倍（100%增加）与绝经前（1.27[1.01-1.59]）妇女的高血压显著相关，但与围绝经期（1.12[0.99-1.27]）或绝经后（1.09[0.95-1.26]）妇女的高血压无关。结论：高血压在中年妇女中较为常见。hs-CRP与高血压的关联在绝经期是一致的。hs-CRP与高血压的相关性与绝经前妇女的体重指数无关，但与围绝经期或绝经后妇女无关。
Objective: The aim of this study was to determine the prevalence of hypertension in midlife women, characterize the association between high-sensitivity C-reactive protein (hs-CRP) and hypertension in women, and describe differences in hypertension prevalence by menopausal stage.Methods: We included 1,625 women, aged 43 to 55 years, with measurements of hs-CRP and detailed reproductive histories in the Coronary Artery Risk Development in Young Adults study at follow-up year 25. Prevalent hypertension was defined as a systolic blood pressure of 140 mm Hg, or diastolic blood pressure of 90 mm Hg or greater, or use of antihypertensive medications. Logistic regression was used for analysis.Results: The prevalence of hypertension was 25.8%, 37.8%, and 39.0% in premenopausal, perimenopausal, and postmenopausal women, respectively. The median (25th and 75th percentiles) of hs-CRP was 3.08 (1.12, 7.98) mu g/mL and 1.18 (0.48, 3.15) mu g/mL in women with and without hypertension, respectively. After adjusting for confounders, metabolic factors and body mass index, a doubling (100% increment) in hs-CRP levels was significantly associated with hypertension in premenopausal (1.27 [1.01-1.59]), but not in perimenopausal (1.12 [0.99-1.27]) or postmenopausal (1.09 [0.95-1.26]) women.Conclusions: Hypertension was common in midlife women. The association of hs-CRP and hypertension was consistent across menopausal stages. The association of hs-CRP with hypertension was independent of body mass index in premenopausal but not in perimenopausal or postmenopausal women.