The post-translational modification profile of the forkhead transcription factor FOXL2 suggests the existence of parallel processive/concerted modification pathways
The post-translational modification profile of the forkhead transcription factor FOXL2 suggests the existence of parallel processive/concerted modification pathways
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DOI：
10.1002/pmic.200800084
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发表时间：
2008-08-01
期刊：
影响因子：
3.4
通讯作者：
Veitia, Reiner A.
中科院分区：
文献类型：
--
作者：
Benayoun, Berenice A.;Auer, Jana;Veitia, Reiner A.
转录因子Forkhead box L亚家族成员2(FOXL2)参与颅面发育和卵巢功能。使用2-DE和免疫印迹，我们发现它在翻译后高度修饰。其迁移特征最突出的特征是存在两个截然不同的修饰“列车”，并且没有中间体。对FOXL2修饰谱的理论分析表明，它经历了平行的过程/协同修饰。中间体的缺乏与糟糕的修饰FOXL2被招募到翻译后的“修饰工厂”中是兼容的。
The transcription factor Forkhead box L subfamily member 2 (FOXL2) is involved in craniofacial development and ovarian function. Using 2-DE and immunoblotting, we show that it is highly modified post-translationally. The most outstanding feature of its migration profile is the presence of two distinct modification "trains" and the absence of intermediates. A theoretical analysis of the modification profile of FOXL2 suggests that it undergoes parallel processive/concerted modifications. The absence of intermediates is compatible with the recruitment of poorly modified FOXL2 into a post-translational "modification factory.".