The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver
The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver
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咖啡抗肝脏肿瘤作用的多方面机制
DOI：
10.1016/j.mehy.2008.06.026
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发表时间：
2008-11-01
影响因子：
4.7
通讯作者：
Dou, Ke-Feng
中科院分区：
文献类型：
--
作者：
Tao, Kai-Shain;Wang, Wen;Dou, Ke-Feng
流行病学研究发现，咖啡消费量与肝癌风险之间存在负相关关系。动物数据支持咖啡的这种化学预防作用。大量的研究已经致力于确定可能对这些有益效果负责的咖啡成分。根据现有的文献，三种主要成分，即咖啡二萜类化合物咖啡醇和咖啡豆醇（C + K），咖啡因和绿原酸有助于有益效果。这些成分诱导II相解毒和抗氧化酶，以及抑制I相活化酶的表达或降低其活性，从而防止致癌。这些组分靶向共同途径的不同阶段，Kelch样ECH相关蛋白1（Keap 1）- NF-E2相关因子-2（Nrf 2）-抗氧化剂反应元件（ARE）信号途径，从而改变抗肿瘤作用中所需基因的ARE依赖性表达。(C)2008爱思唯尔有限公司版权所有。
Epidemiological studies have found an inverse association between coffee consumption and the risk of liver cancer. Animal data support such a chemopreventive effect of coffee. Substantial research has been devoted to the identification of coffee components that may be responsible for these beneficial effects. Based on the current available literature, three major components, i.e. coffee diterpenes cafestol and kahweol (C + K), caffeine and chlorogenic acid contribute to the beneficial effects. These components induce phase II detoxifying and antioxidant enzymes as well as inhibit the expression or decrease the activity of phase I activating enzymes thus prevent carcinogenesis. These components target different stages of a common pathway, Kelch-like ECH-associated protein 1 (Keapl) - NF-E2-related factor-2 (Nrf2) - antioxidant-responsive-element (ARE) signal pathway thus alter the ARE-dependent expression of genes needed in the anti-tumorigenic effects. (C) 2008 Elsevier Ltd. All rights reserved.