Repeatability and Agreement of Swept Source and Spectral Domain Optical Coherence Tomography Evaluations of Thickness Sectors in Normal Eyes
Repeatability and Agreement of Swept Source and Spectral Domain Optical Coherence Tomography Evaluations of Thickness Sectors in Normal Eyes
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DOI：
10.1097/ijg.000000000000536
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发表时间：
2017-02-01
影响因子：
2
通讯作者：
Kim, Chan Yun
中科院分区：
文献类型：
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作者：
Lee, Sang Yeop;Bae, Hyoung Won;Kim, Chan Yun
研究目的：本研究的目的是评估扫频光源光学相干断层扫描（SSOCT）的临床疗效，我们比较了使用SS-OCT获得的厚度测量的器械内重复性与使用谱域OCT（SD-OCT）获得的测量的重复性，并评估了厚度测量的器械间一致性。材料和方法：这项横断面前瞻性研究涉及使用2种不同OCT系统对健康受试者的视乳头周围视网膜神经纤维层（PP-RNFL）和神经节细胞-内网状层厚度进行3次连续测量。计算组内相关系数（ICC）和变异系数，并比较研究组间的重复性和一致性。比较了每种OCT系统的器械内ICC，并使用Bland-Altman图来评估其一致性。结果：分析了58例健康受试者（25例男性和33例女性）的58只眼。SS-OCT图像在检查的每个扇区中产生比SD-OCT图像更大的PP-RNFL厚度值。相比之下，SD-OCT图像产生的黄斑神经节细胞丛状层厚度值大于SS-OCT图像。对于SS-OCT，所有扇区的器械内ICC均为Z0.9。然而，对于SD-OCT，3个PP-RNFL测量区域的相关系数< 0.9。器械间ICC变化更大，低于器械内值，因为OCT设备之间的厚度测量值不同。结论：即使是同一个主题，系统之间的测量值也不同。SS-OCT具有与SD-OCT相似的器械内重复性，这些结果支持SS-OCT的临床应用。
Purpose of the Study: The purpose of the study was to evaluate the clinical efficacy of swept-source optical coherence tomography (SSOCT), we compared the intradevice repeatability of thickness measurements obtained using SS-OCT to that of measurements obtained using spectral domain OCT (SD- OCT), and assessed the interdevice agreement of thickness measurements.Materials and Methods: This cross-sectional prospective study involved 3 consecutive measurements of peripapillary retinal nerve fiber layer (PP- RNFL) and ganglion cell-inner plexiform layer thickness in healthy subjects, using 2 different OCT systems. Intraclass correlation coefficients (ICCs) and coefficients of variability were calculated and compared for repeatability and agreement between study groups. Intradevice ICCs for each OCT system were compared, and Bland-Altman plots were used to evaluate their agreement.Results: Fifty-eight eyes from 58 healthy subjects (25 men and 33 women) were analyzed. SS-OCT images yielded larger PP- RNFL thickness values than SD- OCT images in every sector examined. In contrast, SD-OCT images yielded larger macular ganglion cellinner plexiform layer thickness values than SS-OCT images. For SS-OCT, intradevice ICCs were Z0.9 for all sectors. However, for SD- OCT, the 3 PP- RNFL measurement sectors had correlation coefficients < 0.9. Interdevice ICCs varied more and were lower than intradevice values, because thickness measurement values differed between the OCT devices.Conclusions: Measurements differed between systems even for the same subject. SS-OCT had an intradevice repeatability similar to that of SD-OCT. These findings support the clinical application of SS-OCT.