Blood oxygenation level dependent contrast resting state networks are relevant to functional activity in the neocortical sensorimotor system
Blood oxygenation level dependent contrast resting state networks are relevant to functional activity in the neocortical sensorimotor system
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DOI：
10.1007/s00221-005-0059-1
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发表时间：
2005-12-01
影响因子：
2
通讯作者：
Matthews, PM
中科院分区：
文献类型：
--
作者：
De Luca, M;Smith, S;Matthews, PM
使用两个定量标准检验了静息状态网络(RSN)在整个大脑获得的血氧水平依赖(BOLD)信号变化与功能网络之间的相关性：(1)主要RSN相关簇的定位和同一受试者BOLD fMRI信号变化中定义的任务相关最大值；以及(2)感觉运动皮质BOLD fMRI信号变化的相对半球偏侧化(LI)。RSN的定义是基于与初级感觉运动皮质中“种子”体素的信号变化相关的信号变化。我们发现在RSN中相关的BOLD信号变化和与手部运动相关的激活极大值之间存在普遍密切的空间对应关系。手部主动运动时常规的BOLD功能磁共振成像显示，受试者感觉运动皮质LI的相对半球偏侧化存在预期的广泛差异。主动手运动任务的LIS与RSN有较好的相关性(r=0.74p&0.001)。因此，RSN去了。运动皮质的解剖学相关区域，并随着感觉运动皮质与手运动相互作用的半球偏侧化的功能相关变化而变化。
The relevance of correlations between blood oxygenation level dependent ( BOLD) signal changes across the brain acquired at rest ( resting state networks, or RSN) to functional networks was tested using two quantitative criteria: ( 1) the localisation of major RSN correlation clusters and the task- related maxima defined in BOLD fMRI signal changes from the same subjects; and ( 2) the relative hemispheric lateralisation ( LI) of BOLD fMRI signal changes in sensorimotor cortex. RSN were defined on the basis of signal changes correlated with that of a `` seed'' voxel in the primary sensorimotor cortex. We found a generally close spatial correspondence between clusters of correlated BOLD signal change in RSN and activation maxima associated with hand movement. Conventional BOLD fMRI during active hand movement showed the expected wide variation in relative hemispheric lateralisation of LI for sensorimotor cortex across the subjects. There was a good correlation between LIs for the active hand movement task and the RSN ( r= 0.74, p < 0.001). The RSN thus de. ne anatomically relevant regions of motor cortex and change with functionally relevant variations in hemispheric lateralisation of sensorimotor cortical interactions with hand movement.