SEVERITY OF DEMENTIA IN ALZHEIMER-DISEASE AND NEUROFIBRILLARY TANGLES IN MULTIPLE BRAIN-REGIONS
SEVERITY OF DEMENTIA IN ALZHEIMER-DISEASE AND NEUROFIBRILLARY TANGLES IN MULTIPLE BRAIN-REGIONS
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DOI：
10.1097/00002093-199100510-00001
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发表时间：
1991-03-01
影响因子：
2.1
通讯作者：
MILLER, CA
中科院分区：
文献类型：
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作者：
SAMUEL, WA;HENDERSON, VW;MILLER, CA
我们研究了选定的皮质和皮质下部位神经原纤维缠结(NFT)的数量与临床病程和痴呆症严重程度的关系。16名临床诊断为“可能的”阿尔茨海默病的患者被标准化的神经心理学仪器筛查，以评估痴呆症的严重程度。尸检时从下丘脑、四个新皮质区域和Meynert基底核获得组织；用硫代黄素S染色检测NFT计数。总体而言，下丘脑显示的NFT最多，其次是视觉联想和运动前皮质、初级皮质(运动和视觉)和基底核。NFT计数与病程呈显著正相关，运动皮质NFT计数与病程呈显著正相关。神经心理功能障碍仅在基底核与NFT计数显著相关。反过来，基底核的计数与除下丘脑外的所有其他脑区的计数可靠地相关。下丘脑的计数与其他任何区域均无相关性。在与功能相关的部位，初级运动皮质和运动前皮质或初级和视觉关联皮质内的NFT数量显著或接近显著相关，而运动和视觉皮质计数没有相关性。我们的结果表明，尽管NFT在基底核的积聚比在许多其他脑区要少，但该结构中的计数与疾病的严重程度和病程以及其他区域的NFT积聚密切相关。
We studied the relationship of numbers of neurofibrillary tangles (NFTs) in selected cortical and subcortical sites to the duration of clinical disease and severity of dementia. Sixteen patients with a clinical diagnosis of "probable" Alzheimer disease were screened with standardized neuropsychological instruments to estimate the severity of dementia. Tissues were obtained at autopsy from the subiculum, four neocortical areas, and the nucleus basalis of Meynert; NFT counts were assessed with the thioflavin S stain. Overall, the subiculum showed the most NFTs, followed by visual association and premotor cortices, primary cortex (motor and visual), and the nucleus basalis. NFT counts were significantly positively correlated with the duration of disease in the nucleus basalis and less strongly in the motor cortex. Neuropsychological impairment was significantly correlated with NFT counts only in the nucleus basalis. In turn, counts in the nucleus basalis were reliably correlated with those in all other brain regions except the subiculum. Counts in the subiculum showed no correlation with any other area. Numbers of NFTs within functionally related sites, the primary motor and premotor cortices or primary and visual association cortices, were significantly or near-significantly correlated, whereas motor and visual cortical counts showed no intercorrelation. Our results indicate that although there is less NFT accumulation in the nucleus basalis than in many other brain regions, counts in this structure bear a close relationship to disease severity and duration and to NFT accumulation in other regions.