Respiratory reactance in forced oscillation technique reflects disease stage and predicts lung physiology deterioration in idiopathic pulmonary fibrosis
Respiratory reactance in forced oscillation technique reflects disease stage and predicts lung physiology deterioration in idiopathic pulmonary fibrosis
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DOI：
10.1016/j.resp.2020.103386
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发表时间：
2020-04-01
影响因子：
2.3
通讯作者：
Takahashi, Hiroki
中科院分区：
文献类型：
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作者：
Mori, Yuki;Nishikiori, Hirotaka;Takahashi, Hiroki
背景：特发性肺纤维化(IPF)是一种慢性进行性疾病。虽然肺功能测试(PFT)对评估IPF的进展是有用的，但在晚期病例中获得足够的结果可能是具有挑战性的。相反，强迫振荡技术(FOT)可以无创实施，即使在肺功能严重恶化的患者中也是如此。方法：对97例IPF患者的PFT和FOT数据进行分析。结果：FOT的呼吸电抗(XRS)成分，特别是吸气相的XRS成分与PFT值相关。进展期患者的5赫兹电抗(X5)较低，共振频率(Fres)和低频电抗面积(ALx)较高。XRS的纵向劣化也被观察到。结论：FOT的XRS成分，尤其是吸气期的XRS成分，反映了IPF患者限制性呼吸功能障碍和病情严重程度。
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease. Although pulmonary function test (PFT) is useful for evaluating the progression of IPF, obtaining adequate results in advanced cases can be challenging. Conversely, the forced oscillation technique (FOT) can be noninvasively performed, even in patients with severely deteriorated lung function. In this study, the usefulness of FOT for the evaluation of IPF disease status was investigated.Methods: We analyzed the PFT and FOT data of 97 patients with IPF.Results: The respiratory reactance (Xrs) components of FOT, especially in the inspiratory phase, correlated with the PFT values. Patients with advanced disease had significantly lower reactance at 5 Hz (X5), higher resonant frequency (Fres) and low-frequency reactance area (ALX). The longitudinal deterioration of Xrs was also observed. Moreover, X5 in the inspiratory phase predicted subsequent lung capacity deterioration.Conclusion: The Xrs components of FOT, especially in the inspiratory phase, reflected restrictive ventilatory impairment and disease severity in patients with IPF.