Daunorubicinol, a major metabolite of daunorubicin: isolation from human urine and enzymatic reactions.

Daunorubicinol, a major metabolite of daunorubicin: isolation from human urine and enzymatic reactions.
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柔红霉素,柔红霉素的主要代谢物:从人尿液中分离和酶促反应。

DOI:
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发表时间:
1971
影响因子:
3.5
通讯作者:
N. Bachur
N. Bachur
中科院分区:
医学2区
文献类型:
--
作者:
N. Bachur

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A major metabolite of daunorubicin from human urine and enzymatic reactions was isolated and characterized. Comparative data from thin-layer chromatography, infrared spectroscopy, mass spectroscopy and chemical derivatization of daunorubicin, adriamycin and the metabolite indicated the metabolite to be the 13-hydroxydaunorubicin, daunorubicinol. The hydrolytic product of daunorubicinol, daunorubicinol aglycone, was a second metabolite.