Polymer Surfaces Possessing Minimal Interaction with Blood Components
Polymer Surfaces Possessing Minimal Interaction with Blood Components
复制标题
与血液成分相互作用最小的聚合物表面
DOI：
10.1007/978-1-4613-2433-1_10
复制
发表时间：
1984
期刊：
影响因子：
14
通讯作者：
Y. Tamada
中科院分区：
文献类型：
--
作者：
Y. Ikada;M. Suzuki;Y. Tamada
对于血液相容表面的分子设计，必须了解在外来表面发生凝血的机制。近年来凝血生化研究的进展揭示了血栓形成复杂的级联过程中涉及的许多主要反应。虽然在分子水平上还不完全清楚血小板粘附以及高分子量激肽原和预钾likrein对Hageman因子（XII）的激活，但众所周知，血栓的形成是由血液成分与外源聚合物表面相互作用引发的(1)。目前尚不清楚哪种血液成分在触发反应中起决定性作用，但关键的反应似乎涉及一些血浆蛋白，这些蛋白将在几秒钟内被吸附到与血液接触的聚合物表面。血小板粘附可随蛋白质吸附而发生。因此，血浆蛋白在聚合物表面的吸附一直是许多研究的目标(2)。
For molecular design of blood-compatible surfaces it is essential to have knowledge of the mechanism of clotting occurring on the foreign surfaces. The recent progress on the biochemistry of blood coagulation has disclosed much of primary reactions involved in the complicated cascade process of thrombus formation. Although platelet adhesion as well as the activation of Hageman factor (XII) by high-molecular-weight kininogen and prekallikrein, are not completely made clear in the molecular level, it is well known that the thrombus formation is triggered by an interaction between blood components and the foreign polymer surface1). It is not clear which blood component plays a decisive role in the trigger reaction, but the key reaction seems to involve some plasma proteins which will be adsorbed within a few seconds to a polymer surface brought into contact with blood. Platelet adhesion may follow the protein adsorption. Therefore, the adsorption of plasma proteins to polymer surfaces has been the objective of numerous investigations2).