Short chain carboxylic acids decrease human gingival keratinocyte proliferation and increase apoptosis and necrosis.
Short chain carboxylic acids decrease human gingival keratinocyte proliferation and increase apoptosis and necrosis.
复制标题
短链羧酸减少人牙龈角质形成细胞增殖并增加细胞凋亡和坏死。
DOI：
10.1111/j.1600-051x.1998.tb02446.x
复制
发表时间：
1998
影响因子：
6.7
通讯作者：
Niederman,R
中科院分区：
文献类型：
--
作者：
Sorkin,BC;Niederman,R
Epithelia are key barriers to infections. In periodontal disease, the gingival sulcular epithelium becomes ulcerated. In this report, we test the hypothesis that short‐chain carboxylic acids (SCCA) inhibit keratinocyte proliferation, increase necrosis and apoptosis, and may thus promote ulceration. SCCA produced by bacteria are present at millimolar concentrations in the periodontal pockets of subjects with periodontal disease. SCCA concentrations are higher in subjects with severe disease than in those with mild disease, and are not detectable in healthy subjects. Cell proliferation is critical for maintenance of epithelial barrier function. All SCCA tested, when neutralized, decreased epithelial cell proliferation (as measured by3H‐thymidine incorporation) in a dose‐dependent manner. We found that epithelial cell viability decreased with increasing SCCA concentrations, accounting at least partly for the decreased3H‐thymidine incorporation. For all conditions we tested. SCCA‐induced apoptosis preceeded and exceeded necrosis. While the molecular mechanism(s) for these effects remain to be determined, the results indicate that SCCA derived from caries‐ or periodontal disease‐associated bacteria could alter gingival barrier function.
