POSTSYNAPTIC INDUCTION AND PRESYNAPTIC EXPRESSION OF HIPPOCAMPAL LONG-TERM DEPRESSION
POSTSYNAPTIC INDUCTION AND PRESYNAPTIC EXPRESSION OF HIPPOCAMPAL LONG-TERM DEPRESSION
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DOI：
10.1126/science.7909958
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发表时间：
1994-05-20
期刊：
影响因子：
56.9
通讯作者：
SIEGELBAUM, SA
中科院分区：
文献类型：
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作者：
BOLSHAKOV, VY;SIEGELBAUM, SA
长时程抑制（LTD）是突触效能的活动依赖性降低，其与其对应物长时程增强一起被认为是哺乳动物脑中学习和记忆的重要细胞机制。在新生大鼠海马CA 1区锥体神经元LTD的诱导依赖于突触后钙离子通过L-型电压门控钙通道与代谢型谷氨酸受体的激活配对进入。尽管LTD是在突触后诱发的，但它是由于突触前末梢递质释放的长期减少所致。这表明LTD可能需要逆行信使的产生。
Long-term depression (LTD) is an activity-dependent decrease in synaptic efficacy that together with its counterpart, long-term potentiation, is thought to be an important cellular mechanism for learning and memory in the mammalian brain. The induction of LTD in hippocampal CA1 pyramidal neurons in neonatal rats is shown to depend on postsynaptic calcium ion entry through L-type voltage-gated calcium channels paired with the activation of metabotropic glutamate receptors. Although induced postsynaptically, LTD is due to a long-term decrease in transmitter release from presynaptic terminals. This suggests that LTD is likely to require the production of a retrograde messenger.