Novel window on early human neurodevelopment via fetal exosomes in maternal blood.
Novel window on early human neurodevelopment via fetal exosomes in maternal blood.
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DOI：
10.1002/acn3.296
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发表时间：
2016-05
影响因子：
5.3
通讯作者：
Goetzl EJ
中科院分区：
文献类型：
--
作者：
Goetzl L;Darbinian N;Goetzl EJ
宫内不良暴露会扰乱胎儿大脑发育，耗尽神经元亚群，抑制正常突触连接的形成。解开人类神经发育障碍的确切机制和时机的一个主要障碍是几乎完全缺乏敏感的非侵入性评估。我们提出了从母体血浆中分离胎儿神经元外体的新方法，作为一个非侵入性的平台，用于测试怀孕早期胎儿神经发育的各个方面。我们的方法学代表着在理解人体系统体内损伤机制方面的重要突破，并有可能用于监测寻求促进胎儿大脑健康的临床干预措施。
Adverse in utero exposures can disrupt fetal brain development, deplete subpopulations of neurons and inhibit formation of normal synaptic connections. A major roadblock to unraveling the precise mechanisms and timing of human neurodevelopmental derangement is the almost complete absence of sensitive noninvasive assessments. We present novel methods for isolating fetal neuronal exosomes from maternal plasma as a noninvasive platform for testing aspects of fetal neurodevelopment as early as the 1st trimester. Our methodology represents an important breakthrough both in understanding mechanisms of injury in vivo in a human system and potentially for monitoring clinical interventions seeking to promote fetal brain health.