Depression in chronic rhinosinusitis: A controlled cohort study
Depression in chronic rhinosinusitis: A controlled cohort study
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DOI：
10.2500/ajra.2016.30.4290
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发表时间：
2016-03-01
影响因子：
2.6
通讯作者：
Soler, Zachary M.
中科院分区：
文献类型：
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作者：
Schlosser, Rodney J.;Storck, Kristina;Soler, Zachary M.
背景资料：慢性鼻窦炎（CRS）患者的抑郁症诊断不足，但显着影响治疗结果和卫生保健utilization.Objective：比较未诊断的抑郁症在CRS队列与健康，non-CRS control coherent.Methods：有症状的CRS患者和non-CRS control coherent. Methods：进行病例对照研究。采用Beck抑郁量表II（BDI）对42例CRS患者和88例无CRS病史的对照组患者进行统计学分析，并分析其与抑郁症的相关性。CRS和对照组患者中医生诊断的抑郁症相当（分别为6%和9%）。与对照组相比，CRS患者中BDI检测到的抑郁更高（分别为31%和14.8%; p = 0.031）。即使控制了共病哮喘、过敏和阿司匹林敏感性，CRS患者的BDI评分也较高。当检查息肉状态时，没有息肉的患者比对照组有更多的抑郁症（38%对14.8%; p = 0.048）。CRS患者的BDI躯体分量表评分更差（p = 0.004），而认知分量表倾向于显着性（p = 0.081）。结论：抑郁可能是更常见的CRS比以前认识到的，特别是在没有息肉的患者。CRS中BDI的躯体子量表评分增加，可能会影响未来的治疗结果。
Background: Depression in patients with chronic rhinosinusitis (CRS) is underdiagnosed but significantly impacts treatment outcomes and health care utilization.Objective: To compare undiagnosed depression in a CRS cohort with a healthy, non-CRS control cohort.Methods: A case-control study of patients with symptomatic CRS and a non-CRS control cohort was performed. Demographic and comorbidity factors were correlated to depression-specific outcomes by using the Beck Depression Inventory II (BDI).Results: We enrolled 42 patients with CRS and 88 control patients with no history of CRS. Physician-diagnosed depression was equivalent in CRS and control patients (6% and 9%, respectively). BDI-detected depression was higher among patients with CRS compared with controls (31% versus 14.8%, respectively; p = 0.031). BDI scores were higher in patients with CRS even when controlling for comorbid asthma, allergy, and aspirin sensitivity. When examined by polyp status, the patients without polyps had more depression than did the controls (38% versus 14.8%; p = 0.048). The somatic subscale scores of the BDI were worse in patients with CRS (p = 0.004), whereas the cognitive subscale trended toward significance (p = 0.081).Conclusion: Depression may be more common in CRS than previously recognized, especially in patients without polyps. Somatic subscale scores of the BDI are increased in CRS and may impact future treatment outcomes.