Angiographic Atlas of the Visceral Vascular Anatomy in Translational Rat Models
Angiographic Atlas of the Visceral Vascular Anatomy in Translational Rat Models
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DOI：
10.1016/j.jvir.2019.03.005
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发表时间：
2019-12-01
影响因子：
2.9
通讯作者：
Gade, Terence P. F.
中科院分区：
文献类型：
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作者：
Shi, Donghua;Kiefer, Ryan M.;Gade, Terence P. F.
目的：表征 2 个转化模型中大鼠内脏脉管系统的血管造影和横截面成像解剖学特征。材料和方法：动物研究是根据机构指南和机构动物护理和使用委员会的批准进行的。通过左颈总动脉或右股总动脉入路，对 65 只 Wistar 和 50 只 Sprague-Dawley 雄性大鼠进行了数字减影动脉造影的回顾性检查。对大鼠进行腹部 MR 成像，以关联成像模式。结果：在 3 个位置进行主动脉造影，包括颅侧至腹腔动脉、颅侧至肾动脉和颅侧至尾部（下）肠系膜动脉，从而能够表征所有 65 只 Wistar 大鼠的内脏分支动脉。对主动脉的一级、二级和三级分支血管进行选择性动脉造影，以表征正常和变异的解剖结构。对 65 只 Wistar 和 10 只 Sprague-Dawley 大鼠的腹腔动脉、65 只 Wistar 和 50 只 Sprague-Dawley 大鼠的肝总动脉以及 43 只 Wistar 大鼠的颅肠系膜动脉进行了专门的选择性动脉造影。 MR 成像能够与脑叶和门静脉解剖结构建立关联。结论：对这些大鼠模型的动脉造影和 MR 成像分析将为转化研究人员提供开发用于介入放射学小动物研究的新血管内方案所需的解剖细节。
Purpose: To characterize angiographic and cross-sectional imaging anatomy of the rat visceral vasculature in 2 translational models.Materials and Methods: Animal studies were conducted in accordance with institutional guidelines and approval of the Institutional Animal Care and Use Committees. Retrospective review of digital subtraction arteriography was performed in 65 Wistar and 50 Sprague-Dawley male rats through a left common carotid artery or right common femoral artery approach. MR imaging of the abdomen was performed on the rats to correlate imaging modalities.Results: Aortography was performed in 3 locations, including cranial to the celiac artery, cranial to the renal arteries, and cranial to the caudal (inferior) mesenteric artery, enabling characterization of the visceral branch arteries in all 65 Wistar rats. Selective arteriography of first-, second-, and third-order branch vessels of the aorta was performed allowing characterization of normal and variant anatomy. Dedicated selective arteriography was performed of the celiac artery in 65 Wistar and 10 Sprague-Dawley rats, of the common hepatic artery in 65 Wistar and 50 Sprague-Dawley rats, and of the cranial mesenteric artery in 43 Wistar rats. MR imaging enabled correlation with the lobar and portal venous anatomy.Conclusions: Analysis of arteriography and MR imaging in these rat models will provide translational researchers with anatomic details needed to develop new endovascular protocols for small animal research in interventional radiology.