Visceral fat obesity increases serum DPP-4 levels in men with type 2 diabetes mellitus
Visceral fat obesity increases serum DPP-4 levels in men with type 2 diabetes mellitus
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DOI：
10.1016/j.diabres.2016.04.027
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发表时间：
2016-06-01
影响因子：
5.1
通讯作者：
Sugimoto, Toshitsugu
中科院分区：
文献类型：
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作者：
Tanaka, Sayuri;Kanazawa, Ippei;Sugimoto, Toshitsugu
目的：2型糖尿病（T2DM）患者血清DPP-4水平与内脏脂肪量之间的关系尚不清楚。因此，本研究旨在探讨 T2DM 患者内脏脂肪堆积和代谢综合征与血清 DPP-4 水平的关系。方法：通过对 135 名从未服用过 DPP-4 抑制剂或 GLP-1 受体激动剂的 T2DM 男性进行计算机断层扫描来评估内脏和皮下脂肪面积。我们研究了血清 DPP-4 水平与内脏脂肪面积以及是否存在代谢综合征之间的关联。结果：根据年龄、T2DM 病程、体重指数、血清肌酐和 HbA1c 调整后的多元回归分析显示，血清 DPP-4 水平与内脏脂肪面积呈正相关（β = 0.25，p = 0.04），但与皮下脂肪面积无关（β = -0.18，p = 0.13）。在针对上述混杂因素进行调整的逻辑回归分析中，血清 DPP-4 水平与内脏脂肪肥胖和代谢综合征呈正相关[比值比 (OR) = 1.63，每标准差 (SD) 增加 95% 置信区间 (CI) = 1.00-2.66，p = 0.04； OR = 1.77，95% CI = 1.09-2.88/SD 增加，p = 0.02，分别]。结论：本研究表明，血清 DPP-4 水平与 T2DM 男性内脏脂肪堆积和代谢综合征的存在呈正相关且特异性相关。 (C) 2016 Elsevier Ireland Ltd. 保留所有权利。
Objective: The relationship between serum DPP-4 level and visceral fat mass is still unclear in type 2 diabetes mellitus (T2DM). This study thus aimed to examine the association of visceral fat accumulation and metabolic syndrome with serum DPP-4 levels in T2DM.Methods: Visceral and subcutaneous fat areas were evaluated by performing computed tomography scan in 135 men with T2DM, who had never taken DPP-4 inhibitors or GLP-1 receptor agonists. We investigated the association between serum DPP-4 levels and visceral fat area as well as the presence of metabolic syndrome.Results: Multiple regression analysis adjusted for age, duration of T2DM, body mass index, serum creatinine, and HbA1c showed that serum DPP-4 levels were positively associated with visceral fat area (beta = 0.25, p = 0.04), but not subcutaneous fat area (beta = -0.18, p = 0.13). In logistic regression analyses adjusted for the confounding factors described above, serum DPP-4 levels were positively associated with visceral fat obesity and metabolic syndrome [odds ratio (OR) = 1.63, 95% confidence interval (CI) = 1.00-2.66 per standard deviation (SD) increase, p = 0.04; OR = 1.77, 95% CI = 1.09-2.88 per SD increase, p = 0.02, respectively].Conclusions: The present study showed that serum DPP-4 level was positively and specifically associated with accumulation of visceral fat and the presence of metabolic syndrome in men with T2DM. (C) 2016 Elsevier Ireland Ltd. All rights reserved.