IMPROVED VISUALIZATION OF POLYPOIDAL CHOROIDAL VASCULOPATHY LESIONS USING SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY
IMPROVED VISUALIZATION OF POLYPOIDAL CHOROIDAL VASCULOPATHY LESIONS USING SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY
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DOI：
10.1097/iae.0b013e3181884fbf
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发表时间：
2009-01-01
影响因子：
3.3
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
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作者：
Ojima, Yumiko;Hangai, Masanori;Yoshimura, Nagahisa
目的：利用光谱域光学相干断层扫描（SD-OCT）报道息肉样脉络膜血管病变眼视网膜色素上皮下血管病变的层析特征。设计：回顾性观察病例系列。方法：对21例息肉样脉络膜血管病变患者的21只眼的血管造影和SD-OCT原型系统图像进行比较，以识别三维和增强SD-OCT图像上可见的视网膜下色素上皮异常。结果：21眼血管造影均可见分支血管网，至少1个息肉样病变；10只眼出现色素上皮脱离（PED）。SD-OCT在21只眼中均显示高反射率的细直线-布鲁氏膜-与分支血管网相关，息肉样病变19只（90%）；10只眼中有9只（90%）患有PED。在SD-OCT图像上，21只眼睛中有20只（95%）的血管异常在清晰描绘的视网膜色素上皮异常切片和Bruch膜之间呈现中等反射率。血管造影发现的息肉样脉络膜病变血管异常（息肉样病变和分支血管网络）。结论：增强的SD-OCT成像清晰地描绘了与血管造影显示的息肉样脉络膜病变血管异常相同位置的视网膜色素上皮异常区域下的Bruch膜。
Purpose: To report the tomographic features of vascular lesions beneath the retinal pigment epithelium in eyes with polypoidal choroidal vasculopathy by using spectral-domain optical coherence tomography (SD-OCT). Design: Retrospective observational case series.Methods: Angiograms and images obtained using the prototype SD-OCT system were compared for 21 eyes of 21 patients with polypoidal choroidal vasculopathy to identify sub-retinal pigment epithelium abnormalities visible on three-dimensional and enhanced SD-OCT images.Results: On angiography, a branching vascular network and at least 1 polypoidal lesion were visible in all 21 eyes; 10 eyes also had pigment epithelial detachment (PED). SD-OCT revealed a thin straight line of high reflectivity-Bruch's membrane-associated with the branching vascular network in all 21 eyes, polypoidal lesions, 19 (90%) of the 21 eyes; and PED, 9 (90%) of the 10 eyes with PED. The vascular abnormalities of polypoidal choroidal vasculopathy (polypoidal lesion and branching vascular network) identified with angiograms were visualized on SD-OCT images in 20 of the 21 eyes (95%) as areas of moderate reflectivity between the clearly delineated abnormal section of retinal pigment epithelium and Bruch's membrane.Conclusions: Enhanced SD-OCT imaging clearly depicted Bruch's membrane beneath areas of abnormal retinal pigment epithelium in the same locations where the vascular abnormalities of polypoidal choroidal vasculopathy were evident on angiography.