New diterpene glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber
New diterpene glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber
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DOI：
10.1021/np010503y
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发表时间：
2002-05-01
影响因子：
5.1
通讯作者：
Elyakov, GB
中科院分区：
文献类型：
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作者：
Afiyatullov, SS;Kalinovsky, AI;Elyakov, GB
从一株条斑顶藻KMM 4401菌株中分离得到3个新的二萜糖苷，分别为绿烯糖苷0(1)、P(2)和Q(3)。根据红外光谱和核磁共振数据确定其结构为beta-D-altropyranosido-19-isopimara-8(14)，15-diene-7alpha，3beta-diol(1)，beta-D-altropyranosido-19-7-oxoisopimara-8(9)，15-diene-3beta-ol(2)和beta-D-mannopyranosido-19-isopimara-7，15-diene-3beta-ol(3)。并对其细胞毒活性进行了检测。
Three new diterpene glycosides, virescenosides 0 (1), P (2), and Q (3), have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures were determined on the basis of HRMALDIMS and NMR data as beta-D-altropyranosido-19-isopimara-8(14),15-diene-7alpha,3beta-diol (1), beta-D-altropyranosido-19-7-oxoisopimara-8(9),15-diene-3beta-ol (2), and,beta-D-mannopyranosido-19-isopimara-7,15-diene-3beta-ol (3). The cytotoxic activity of the virescenosides was examined.