In memoriam: Wylie Walker Vale, Jr.
In memoriam: Wylie Walker Vale, Jr.
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悼念：Wylie Walker Vale, Jr.
DOI：
10.1038/mp.2012.132
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发表时间：
2012
影响因子：
11
通讯作者：
Gold,PW
中科院分区：
文献类型：
--
作者：
Chrousos,GP;Licinio,J;Gold,PW
个人资料：怀利·步行者·瓦尔1941年7月3日出生于得克萨斯州休斯顿。在高中时，他遇到并爱上了他的妻子贝蒂，他们结婚40多年。怀利于1964年获得莱斯大学生物学学士学位，1969年获得贝勒医学院生理学和生物化学博士学位。1970年，他们结婚后，他和贝蒂搬到了加州的拉霍亚，在那里他开始了他在诺贝尔奖获得者罗杰·吉勒明实验室的索尔克研究所的杰出科学生涯。1978年，Wylie在Salk建立了他的独立实验室，在那里他继续他对内分泌肽的开创性工作。怀利和贝蒂享受了完整的生活在一起，提高他们的两个可爱的女儿，伊丽莎白和苏珊娜，陶醉在他们的生活，他们的婚姻和被祝福与他们的第一个孙子塞莱斯特的到来。2012年1月3日，怀利在夏威夷美丽的毛伊岛哈纳的家中平静地去世，享年70岁。职业生涯：在他杰出的科学生涯中，Wylie发现了许多激素和生长因子，这些激素和生长因子在中枢神经系统、内分泌系统和免疫系统之间提供了分子联系。1981年，Wylie和他的团队发现了促肾上腺皮质激素释放因子（CRF或CRH），这是生物体对压力的内分泌反应的主要调节因子。这种激素后来被认为是中枢神经系统中真正的神经递质，对抑郁症和焦虑相关疾病有影响，并有效地启动了我们今天所知的神经肽领域。几年后，Wylie扩展了这一开创性的发现，发现了生长激素释放因子，以及CRF家族中的另外三种肽，尿皮质素，它们是食欲，代谢，生长，生殖和心血管功能的重要调节剂。怀利工作的影响最好的例证是基于他的发现正在进行的临床试验的数量。事实上，每一家主要的制药公司都开发了特定的CRF拮抗剂，用于治疗情绪障碍、物质滥用和其他与压力有关的疾病，如肠易激综合征。分子目前正在创伤后应激障碍的临床试验中取得进展，
Personal: Wylie Walker Vale was born in Houston, Texas, on 3 July 1941. While still in high school, he met and fell in love with his wife Betty to whom he was married for over 40 years. Wylie earned his bachelor’s degree in Biology from Rice University in 1964 and his PhD in Physiology and Biochemistry from the Baylor College of Medicine in 1969. In 1970, after their marriage, he and Betty moved to La Jolla, California, where he began his illustrious scientific career at the Salk Institute in the Laboratory of Nobel Laureate Roger Guillemin. In 1978, Wylie set up his independent laboratory at the Salk, where he continued his groundbreaking work on endocrine peptides. Wylie and Betty enjoyed a full life together raising their two lovely daughters, Elizabeth and Susannah, reveling in their lives, their marriages and being blessed with the arrival of their first grandchild Celeste. On 3 January 2012, Wylie passed away peacefully at the age of 70 in their home in Hana on the beautiful island of Maui, Hawaii, a small piece of the rainforest that he and Betty were remodeling consistent with their love for raw nature. He was truly at peace in their own piece of paradise.Career: During his distinguished scientific career, Wylie discovered a number of hormones and growth factors that provide a molecular link between the central nervous, endocrine and immune systems. In 1981, Wylie and his team discovered corticotropin-releasing factor (CRF or CRH), the primary regulator of an organism’s endocrine response to stress. This hormone would later be recognized as a bona fide neurotransmitter in the central nervous system having implications in depression and anxiety-related disorders and effectively launching the field of neuropeptides as we know it today. A few years later, Wylie extended this seminal discovery with his discovery of growth hormone-releasing factor, as well as three additional peptides within the CRF family, the Urocortins, which are important modulators of appetite, metabolism, growth, reproduction and cardiovascular function. The impact of Wylie’s work can best be exemplified by the number of ongoing clinical trials based on his discoveries. Virtually every major pharmaceutical company has developed specific CRF antagonists for the potential treatment of mood disorders, substance abuse and other stress-related diseases, such as irritable bowel syndrome. Molecules are currently progressing in clinical trials for post-traumatic stress disorder and