LATENT HERPES-SIMPLEX VIRUS TYPE-1 IN HUMAN GENICULATE GANGLIA
LATENT HERPES-SIMPLEX VIRUS TYPE-1 IN HUMAN GENICULATE GANGLIA
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DOI：
10.1007/bf00427213
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发表时间：
1992-06-01
影响因子：
12.7
通讯作者：
NAGASHIMA, K
中科院分区：
文献类型：
--
作者：
FURUTA, Y;TAKASU, T;NAGASHIMA, K
病毒感染。特别是单纯疱疹病毒（HSV）的再激活被认为是特发性周围面神经麻痹（贝尔麻痹）发病机制的可能解释。我们研究了人类膝状神经节是否含有潜伏的HSV 1型（HSV-1）。比较人类膝状神经节和三叉神经节中单纯疱疹病毒感染神经元与潜伏感染神经元的频率。采用原位杂交和免疫组化染色的方法，对8例成人尸体解剖标本中15例膝状神经节和16例三叉神经节进行了检测。在15例膝状神经节中的11例（71%）和16例三叉神经节中的13例（81%）检测到HSV-1基因组。神经节内未见HSV抗原。潜伏感染的神经元发生率在三叉神经节为0.9%，膝状神经节为5.3%。两种神经节的百分比差异是显著的。我们的研究结果表明，潜伏HSV在膝状神经节的再激活是一些疱疹性口炎和特发性周围面神经麻痹病例的可能原因。
Viral infection. especially by reactivation of herpes simplex virus (HSV) has been considered to be a possible explanation for the pathogenesis of idiopathic peripheral facial nerve palsy (Bell's palsy). We investigated whether the geniculate ganglia of man contain latent HSV type 1 (HSV-1). and compared the frequency of HSV-infected ganglia and that of latently infected neurons in human geniculate ganglia and in trigeminal ganglia. From autopsy specimens of eight adults 15 geniculate ganglia and 16 trigeminal ganglia were examined by means of in situ hybridization and immunohistochemical staining. The HSV-1 genome was detected in 11 of the 15 (71 %) geniculate ganglia and in 13 of the 16 (81 %) trigeminal ganglia. No HSV antigen was noted in any of the ganglia. The incidence of latently infected neurons was 0.9 % in the trigeminal ganglia and 5.3 % in the geniculate ganglia. The difference in percentages between the two types of ganglia was significant. Our results suggest that reactivation of latent HSV in the geniculate ganglia is a probable cause of some cases of herpetic stomatitis and of idiopathic peripheral facial nerve palsy.