Inference on haplotype/disease association using parent-affected-child data: The projection conditional on parental haplotypes method
Inference on haplotype/disease association using parent-affected-child data: The projection conditional on parental haplotypes method
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DOI：
10.1002/gepi.20203
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发表时间：
2007-04-01
影响因子：
2.1
通讯作者：
Satten, Glen A.
中科院分区：
文献类型：
--
作者：
Allen, Andrew S.;Satten, Glen A.
我们开发了一种方法，允许在给定个人单倍型的情况下对疾病相对风险的对数线性模型中的参数进行推断，该方法可用于分析病例-父母三重数据。我们的方法对种群分层是稳健的，也可以用于单倍型和环境协变量之间相互作用的影响的推断。我们将我们的结果与Horvath等人的基于家庭的联想测验(FBAT)进行了比较。([20041 Genet.埃皮米诺。26：61-69)，并讨论边际测试，如FBAT中提供的测试，何时可能具有误导性。我们的方法推广了Allen等人以前的结果。([2005]Biillska 92：559-571)，允许缺失的基因型数据和单倍型x环境交互作用。文中还讨论了额外的计算简化。
We develop a method that allows inference on parameters in log-linear models of the relative risk of disease given an individual's haplotypes, that can be used to analyze case-parent trio data. Our methods are robust to population stratification and can also be used for inference on the effect of interactions between haplotypes and environmental covariates. We compare our results with the family-based association test (FBAT) of Horvath et al. ([20041 Genet. Epidemiol. 26:61-69), and discuss when marginal tests, such as those available in FBAT, can be misleading. Our approach generalizes previous results of Allen et al. ([2005] Biometrika 92:559-571), allowing for missing genotype data and haplotype x environment interactions. Additional computational simplifications are also discussed.