Use of a systems biology approach to understand pancreatic β-cell death in Type 1 diabetes
Use of a systems biology approach to understand pancreatic β-cell death in Type 1 diabetes
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DOI：
10.1042/bst0360321
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发表时间：
2008-06-01
影响因子：
3.9
通讯作者：
Ortis, Fernanda
中科院分区：
文献类型：
--
作者：
Eizirik, Decio L.;Moore, Fabrice;Ortis, Fernanda
越来越多的证据表明，T1DM（1型糖尿病）患者p细胞凋亡。细胞凋亡是一个活跃的基因导向过程，最近的观察表明，p细胞凋亡依赖于NF-kappa B（核因子kappa B）和STAT-1（转录信号传感器和激活因子1）等关键转录因子控制的数百个基因的平行和/或顺序的上调和下调。理解这些基因网络的调控，以及它们如何调节p细胞死亡和β细胞与免疫系统之间的“对话”，将需要一个系统生物学的方法来解决这个问题。这将有望使T1DM的治疗研究从“试错法”转向真正由机制驱动的方法。
Accumulating evidence indicates that p-cells die by apoptosis in T1DM (Type 1 diabetes mellitus). Apoptosis is an active gene-directed process, and recent observations suggest that p-cell apoptosis depends on the parallel and/or sequential up- and down-regulation of hundreds of genes controlled by key transcription factors such as NF-kappa B (nuclear factor kappa B) and STAT-1 (signal transducer and activator of transcription 1). Understanding the regulation of these gene networks, and how they modulate P-cell death and the 'dialogue' between beta-cells and the immune system, will require a systems biology approach to the problem. This will hopefully allow the search for a cure for T1DM to move from a 'trial-and-error' approach to one that is really mechanistically driven.