Theta frequency stimulation induces a local form of late phase LTP in the CA1 region of the hippocampus
Theta frequency stimulation induces a local form of late phase LTP in the CA1 region of the hippocampus
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DOI：
10.1101/lm.98905
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发表时间：
2005-11-01
影响因子：
2
通讯作者：
Kandel, ER
中科院分区：
文献类型：
--
作者：
Huang, YY;Kandel, ER
LTP的晚期（L-LTP）通常由重复的高频刺激诱导。这种形式的LTP需要转录和翻译的激活，并导致基因产物在细胞范围内的分布，这些产物可以被其他标记的突触捕获。在这里，我们报告说，θ频率刺激（5赫兹，30秒）应用于Schaetron侧支通路可以诱导一种形式的LTP的晚期阶段，局限于局部的树突状室。即使在孤立的CAI树突中，θ频率LTP的后期也保持不变，并且依赖于树突翻译和肌动蛋白细胞骨架调节，但不依赖于转录。这种局部形式的L-LTP不能被其他突触捕获，表明这种形式的LTP仅限于突触区室。这些结果表明，不同模式的突触刺激可以诱导不同形式的LTP，可能有不同的记忆存储中的作用。
The late phase of LTP (L-LTP) is typically induced by repeated high-frequency stimulation. This form of LTP requires activation of transcription and translation and results in the cell-wide distribution of gene products that can be captured by other marked synapses. Here we report that theta frequency Stimulation (5 Hz, 30 sec) applied to the Schaeffer-collateral pathway can induce a form of late phase of LTP that is restricted locally to the dendritic compartment. The late phase of theta frequency LTP is maintained even in isolated CAI dendrites and is dependant on dendritic translation and actin cytoskeletal regulation, but is independent of transcription. This local form of L-LTP is not accessible to synaptic capture by other synapses, indicating that this form of LTP is restricted to the synaptic compartment. These results indicate that different patterns of synaptic stimulation can induce distinct forms of LTP that may have different roles in memory storage.