Influence of Type 1 Diabetes Mellitus on the Ocular Biometry of Chinese Children
Influence of Type 1 Diabetes Mellitus on the Ocular Biometry of Chinese Children
复制标题
1型糖尿病对中国儿童眼部生物测量的影响
DOI：
10.1155/2019/7216490
复制
发表时间：
2019-02-14
影响因子：
1.9
通讯作者：
Zou, Haidong
中科院分区：
文献类型：
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作者：
Xiao, Ying;Li, Tao;Zou, Haidong
目的比较中国1型糖尿病（T1 DM）儿童与健康儿童的眼生物学指标，并探讨其与糖化血红蛋白（HbA 1c）水平及糖尿病病程的相关性。方法采用病例对照研究方法，对复旦大学附属儿童医院T1 DM儿童与健康儿童进行对照研究。评估参与者的中央角膜厚度（CCT）、前房深度（ACD）、透镜厚度（LT）、K1和K2角膜曲率和眼轴长度（AL）;还进行睫状肌麻痹验光，并获得等效球镜（SE）。获得T1 DM患者的HbA 1c水平。结果T1 DM患儿54例54眼，健康儿童53例53眼。T1 DM组和对照组的平均年龄分别为10.59 ± 3.40岁和9.55 ± 1.89岁，年龄和性别之间的差异不显著（p=0.052，p=0.700）。T1 DM组的平均LT（3.49 ± 0.18）mm，较对照组明显增厚（3.40 ± 0.16 mm）（p=0.018），T1 DM组的平均ACD（3.52 ± 0.26）mm（3.72 ± 0.26 mm）（p < 0.001），CCT、K1、K2、AL和SE无显著差异（分别为p=0.088、p=0.672、p=0.821、p=0.094和p=0.306）。HbA 1c或糖尿病病程与眼生物测量无显著相关性。结论与年龄、性别匹配的健康儿童相比，T1 DM儿童的LT较厚，ACD较浅，但总体屈光度不受影响。在T1 DM儿童中，HbA 1c或糖尿病病程与眼部生物测量无关。
Purpose To compare ocular biometry between children with type 1 diabetes mellitus (T1DM) and healthy children in China and to determine the correlation of ocular biometry with the glycosylated hemoglobin (HbA1c) level and diabetes duration. Methods A case-control study was conducted at Children's Hospital of Fudan University between T1DM children and healthy children. The participants were evaluated for central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), K1 and K2 keratometry, and axial length (AL); also cycloplegic refraction was performed, and spherical equivalent (SE) was acquired. HbA1c levels of the T1DM cases were obtained. Results Fifty-four eyes of 54 children with T1DM and 53 eyes of 53 healthy children were included. The mean age of T1DM group and control group was 10.59 ± 3.40 years and 9.55 ± 1.89 years, respectively, and the differences between age and gender were not significant (p=0.052, p=0.700). The mean LT in T1DM group (3.49 ± 0.18 mm) was thicker than that in the control group (3.40 ± 0.16 mm) (p=0.018), the mean ACD in T1DM group (3.52 ± 0.26 mm) was shallower than that in the control group (3.72 ± 0.26 mm) (p < 0.001), and there were no significant differences of CCT, K1, K2, AL, and SE (p=0.088, p=0.672, p=0.821, p=0.094, and p=0.306, respectively). There was no significant correlation between HbA1c or diabetes duration and ocular biometry. Conclusions Thicker LT and shallower ACD occurred in T1DM children rather than age-matched and sex-matched healthy children, but the overall refraction was not affected. HbA1c or diabetes duration was not correlated with ocular biometry in T1DM children.