Laminar organization of the human fetal cerebrum revealed by histochemical markers and magnetic resonance imaging
Laminar organization of the human fetal cerebrum revealed by histochemical markers and magnetic resonance imaging
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DOI：
10.1093/cercor/12.5.536
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发表时间：
2002-05-01
期刊：
影响因子：
3.7
通讯作者：
Hrabac, P
中科院分区：
文献类型：
--
作者：
Kostovic, I;Judas, M;Hrabac, P
发育中的人类大脑在其分层模式上显示出年龄特异性的变化。其中，基板区是最突出的瞬态室，因为生长的主要传入系统暂时驻留在这个区域，建立突触，并参与细胞的相互作用，是至关重要的后续皮质发育。我们探讨了磁共振成像（MRI）的潜力，用于追踪排卵后15至36周胎儿大脑壁最突出的皮质层（基板区）和其他层状隔室的发育历史。我们发现，人类胎儿大脑壁的MRI分层模式的变化主要是由基板区的变化引起的。细胞外基质（ECM）的组织化学染色能够选择性地显示基板区，并与基板区中MRI信号强度的增加以及丘脑皮质和皮质皮质传入神经的向内生长和积累及其随后重新定位到皮质板的相关性。因此，动态变化的MRI外观的subplate区和组织化学染色的ECM可以用作间接参数的评估正常与干扰展开的关键histogenetic事件，参与产前塑造的人大脑皮层。
The developing human cerebrum displays age-specific changes in its patterns of lamination. Among these, the subplate zone is the most prominent transient compartment because growing major afferent systems temporarily reside in this zone, establish synapses and take part in cellular interactions that are crucial for subsequent cortical development. We explored the potential of magnetic resonance imaging (MRI) for tracing the developmental history of the most prominent cortical layer (the subplate zone) and other laminar compartments of the fetal cerebral wall between 15 and 36 weeks post-ovulation. We found that changes in the MRI lamination pattern of the human fetal cerebral wall are predominantly caused by changes in the subplate zone. Histochemical staining of the extracellular matrix (ECM) enables selective visualization of the subplate zone and correlation with an increase in MRI signal intensity in the subplate zone and ingrowth and accumulation of thalamocortical and corticocortical afferents and their subsequent relocation to the cortical plate. Thus, dynamic changes in the MRI appearance of the subplate zone and histochemical staining of its ECM can be used as indirect parameters for an assessment of normal versus disturbed unfolding of crucial histogenetic events that are involved in prenatal shaping of the human cerebral cortex.