EFFECTS OF BILATERAL LESIONS OF AUDITORY-CORTEX IN MICE ON THE ACOUSTIC STARTLE RESPONSE
EFFECTS OF BILATERAL LESIONS OF AUDITORY-CORTEX IN MICE ON THE ACOUSTIC STARTLE RESPONSE
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DOI：
10.1016/0031-9384(93)90337-f
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发表时间：
1993-12-01
影响因子：
2.9
通讯作者：
WILLOTT, JF
中科院分区：
文献类型：
--
作者：
HUNTER, KP;WILLOTT, JF
本研究采用声惊吓反应（ASR）研究听皮层损伤对脑干介导的听觉行为的影响。在双侧听觉皮层消融前、消融后1天和1个月后，从年轻成年C57 BL/6 J小鼠纵向获得ASR。对照组小鼠接受非听觉皮层损伤。对于一些小鼠，获得了平均脑干诱发反应（ABR），这些表明病变对听觉灵敏度没有影响。手术后一个月，听觉皮层消融的小鼠与对照组在ASR的所有阈上测量上在统计学上没有区别。然而，在听觉皮层消融后1天，实验动物（而不是对照组）表现出ASR幅度的变化（但不是阈值或潜伏期）。当使用80 dB SPL的噪声突发来引起ASR时，振幅减小，但使用110 dB刺激时，振幅增强。研究结果可以解释为两种方式之一：临时干扰调制的ASR通常由听觉皮层;或听觉皮层消融对脑干听觉回路的一般影响，而不是特定的ASR。在任何情况下，如果听觉皮质对ASR发挥调节作用，那么它显然是不必要的和/或在消融后很容易得到补偿。
The acoustic startle response (ASR) was used to investigate the effects of auditory cortical lesions on a brain stem-mediated auditory behavior. The ASRs were obtained longitudinally from young adult C57BL/6J mice before bilateral ablation of auditory cortex, 1 day after ablation, and 1 month later. Control mice received lesions of nonauditory cortex. For some mice, averaged brain stem-evoked responses (ABR) were obtained, and these indicated no effects of lesions on auditory sensitivity. One month after surgery, mice with auditory cortex ablations were statistically indistinguishable from controls on all suprathreshold measures of ASR. However, 1 day after ablation of auditory cortex, experimental animals (but not controls) exhibited a change in ASR amplitude (but not threshold or latency). When a noise burst of 80 dB SPL was used to elicit the ASR, the amplitude was diminished, but with a 110 dB stimulus, amplitude was enhanced. The findings can be interpreted in one of two ways: temporary interference with modulation of the ASR normally performed by auditory cortex; or a general effect of auditory cortex ablation on brain stem auditory circuits not specific to the ASR. In any event, if auditory cortex plays a modulatory role with regard to the ASR, it is apparently nonessential and/or readily compensated for after ablation.