Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test
Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test
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DOI：
10.1016/s0893-133x(99)00100-1
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发表时间：
2000-02-01
影响因子：
7.6
通讯作者：
Lucki, I
中科院分区：
文献类型：
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作者：
López-Rubalcava, C;Lucki, I
Wistar-Kyoto（WKY）缸提供了一个模型的压力诱导的抑郁行为，但它们显示出增强的脆弱性的影响，压力。本研究探讨了WKY和SD大鼠在强迫游泳实验中对不同类型抗抑郁药物的行为反应的差异。在暴露于FST期间，WKY小鼠表现出比SD大鼠显著更大的不动性。去甲肾上腺素能抗抑郁药地昔帕明可剂量依赖性地减少SD大鼠的不动性和增加攀爬行为。在WKY大鼠中，地昔帕明在较低剂量下减少了不动性，并增加了游泳和攀爬行为。氟西汀和8-OH-DPAT能剂量依赖性地减少SD大鼠FST的不动性和增加其游泳行为，但WKY大鼠对氟西汀的反应减弱。这些结果表明，遗传或组成的五个差异可能决定了不同的抗抑郁药化合物在不同的大鼠品系的选择性药理作用的不同的行为概况，这些影响可能与抑郁症患者的抗抑郁反应的遗传异质性。[Neuropsychopharmacology 22：191- 199，2000]（C）1999年美国神经精神药理学学会。出版社：Elsevier Science Inc.
Wistar-Kyoto (WKY) vats provide a model of stressinduced depressive behavior, bemuse they show enhanced vulnerability to the effects of stressors. The present study examined differences in the behavioral response to different types of antidepressant drugs between WKY and Sprague-Dawley (SD) rats in the forced swimming test (FST). WKY mts displayed significantly greater immobility than SD rats during their exposure to the FST. The noradrenergic antidepressant, desipramine, produced a dose-dependent reduction of immobility and increase of climbing behavior in the SD rats. In WKY rats, desipramine reduced immobility at a lower dose and produced increases of both swimming and climbing behavior. The serotonergic compounds, fluoxetine and 8-OH-DPAT, produced dose-dependent reductions of immobility and increases of swimming behavior in the FST in SD mts, but the response to the serotonergic drugs were blunted in WKY rats. These results indicate that genetic or constitutive five differences may determine the distinct behavioral profiles for antidepressant compounds with selective pharmacological effects in different rat strains, and these effects may be related to genetic heterogeneity of antidepressant responses in depressed patients. [Neuropsychopharmacology 22:191-199,2000] (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.