Ruthenium-Catalyzed Oxidative C-H Bond Alkenylations in Water: Expedient Synthesis of Annulated Lactones
Ruthenium-Catalyzed Oxidative C-H Bond Alkenylations in Water: Expedient Synthesis of Annulated Lactones
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DOI：
10.1021/ol201563r
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发表时间：
2011-08-19
期刊：
影响因子：
5.2
通讯作者：
Pospech, Jola
中科院分区：
文献类型：
--
作者：
Ackermann, Lutz;Pospech, Jola
钌催化的交叉脱氢C-H键烯基化在环境友好的水中有效发生，这被用于大范围的氧化苯酞合成。机理研究为氧化烯基化通过乙酸盐辅助下不可逆的 C-H 键金属化进行提供了有力的证据。
Ruthenium-catalyzed cross-dehydrogenative C-H bond alkenylations occurred efficiently in environmentally benign water, which was exploited for an oxidative phthalide synthesis with ample scope. Mechanistic studies provided strong evidence for the oxidative alkenylation to proceed by an irreversible C-H bond metalation via acetate assistance.