REACTIVE OXYGEN SPECIES (ROS) - A FAMILY OF FATE DECIDING MOLECULES PIVOTAL IN CONSTRUCTIVE INFLAMMATION AND WOUND HEALING
REACTIVE OXYGEN SPECIES (ROS) - A FAMILY OF FATE DECIDING MOLECULES PIVOTAL IN CONSTRUCTIVE INFLAMMATION AND WOUND HEALING
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DOI：
10.22203/ecm.v024a18
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发表时间：
2012-07-01
影响因子：
3.1
通讯作者：
Hunt, John A.
中科院分区：
文献类型：
--
作者：
Bryan, Nicholas;Ahswin, Helen;Hunt, John A.
伤口愈合需要活性氧（ROS）的积极和有害影响之间的良好平衡;一组非常有效的分子，限制了成功的组织再生。平衡的ROS反应将对组织进行清创和消毒，并刺激健康的组织更新;受抑制的ROS将导致感染，ROS的升高将破坏健康的基质组织。理解和预测组织内的ROS生态位将大大提高外源性增强和操纵愈合的潜力。增强受伤或患病组织的成功愈合和重塑的组织工程解决方案依赖于白细胞分泌组的建设性和破坏性能力之间的受控平衡，包括ROS。这篇综述全面考虑了白细胞衍生的ROS在组织修复中的作用，特别是在包含生物材料的手术干预中。本文认为，ROS的基本化学，形成，刺激和清除之前，应用此讨论的影响，ROS愈合组织与生物材料。我们还系统地讨论了ROS在白细胞信号和比较和对比实验手段测量ROS。
Wound healing requires a fine balance between the positive and deleterious effects of reactive oxygen species (ROS); a group of extremely potent molecules, rate limiting in successful tissue regeneration. A balanced ROS response will debride and disinfect a tissue and stimulate healthy tissue turnover; suppressed ROS will result in infection and an elevation in ROS will destroy otherwise healthy stromal tissue. Understanding and anticipating the ROS niche within a tissue will greatly enhance the potential to exogenously augment and manipulate healing.Tissue engineering solutions to augment successful healing and remodelling of wounded or diseased tissue rely on a controlled balance between the constructive and destructive capacity of the leukocyte secretome, including ROS.This review comprehensively considers leukocyte derived ROS in tissue repair with particular interest in surgical intervention with inclusion of a biomaterial. The article considers ROS fundamental chemistry, formation, stimulation and clearance before applying this to discuss the implications of ROS in healing tissue with and without a biomaterial. We also systematically discuss ROS in leukocyte signalling and compare and contrast experimental means of measuring ROS.