[Coagulation factors as potential tumour markers in patients with head and neck carcinomas?].
[Coagulation factors as potential tumour markers in patients with head and neck carcinomas?].
复制标题
[凝血因子作为头颈癌患者潜在的肿瘤标志物？]。
DOI：
10.1055/s-0030-1261892
复制
发表时间：
2010
影响因子：
1
通讯作者：
T. Hoffmann
中科院分区：
文献类型：
--
作者：
J. Greve;P. Schuler;M. Baş;M. Adamzik;S. Brandau;D. Arweiler;S. Lang;T. Hoffmann
目标
癌症可通过不同因素影响凝血系统。新陈代谢、新血管形成、氧合和组织压力的局部病理变化以及肿瘤细胞的局部和全身活动是其中的一部分。迄今为止，对头颈癌患者的凝血状况的表征还不够充分。
材料和方法
在一项前瞻性试点研究中，20 名患有头颈部鳞状细胞癌的男性患者在治疗前和治疗后接受了详细的凝血诊断，并与对照组 (n=37) 进行了年龄和性别校正。
结果
对于常规参数 PTT、Quick、TZ 和 INR，两组之间没有差异。对于肿瘤患者，治疗前急性期蛋白如因子 I（纤维蛋白原）、因子 VIII、因子 IX、血管性血友病抗原和活性出现统计显着增加。纤溶酶、因子 II、因子 V 和凝血酶-抗凝血酶-III 复合物 (TAT) 的值也增加，而抗凝血酶-III 的值显着降低。在肿瘤患者中，治疗前激活标记物 TAT 的升高值在肿瘤消融治疗后恢复正常。
结论
TAT 可能适合作为潜在的肿瘤标志物，但也适用于复发肿瘤。为了证明这一点，有必要进行一项持续时间更长、涉及更多患者的研究。
OBJECTIVE
Carcinomas can have influence on the coagulation system by different factors. Locally pathological changes of metabolism, neo-vascularisation, oxygenation and tissue pressure as well as locally and systemically activities of the tumor cells, are part of it. The coagulation situation in patients with head and neck carcinomata is characterized only insufficiently till now.
MATERIAL AND METHODS
In a prospective pilot study 20 male patients with squamous-cell carcinomas of the head and neck area were subjected to a detailed coagulation diagnostics pre and post therapeutically and, age and sex corrected, compared with a control group (n=37).
RESULTS
For the routine parameters PTT, Quick, TZ and INR no differences between the groups could be recognized. For the tumour patients a statistically significant increase arose for the acute phase proteins like factor I (fibrinogen), factor VIII, factor IX, von- Willebrand antigen and activity before therapy. Increased values were found also for plasmin, factor II, factor V and the thrombin-antithrombin-III-complex (TAT) whereas the values for antithrombin-III were degraded significantly. In the tumour patients the pre-therapeutical increased values for the activation marker TAT brought themselves back to normal after the tumour ablative therapy.
CONCLUSIONS
TAT could be suitable as a potential tumour marker but also for relapse tumours. To evidence this, a study of longer duration and with a larger number of patients is necessary.