Ocular infection with herpes simplex virus in nonimmune and immune mice.
Ocular infection with herpes simplex virus in nonimmune and immune mice.
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非免疫和免疫小鼠的单纯疱疹病毒眼部感染。
DOI：
10.1001/archopht.1983.01040010961023
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发表时间：
1983
影响因子：
--
通讯作者：
D. Easty
中科院分区：
文献类型：
--
作者：
A. Tullo;C. Shimeld;W. Blyth;T. Hill;D. Easty
在小鼠单纯疱疹病毒(HSV)1型眼部感染的详细研究中，通过裂隙灯检查、泪膜培养和眨眼反射监测，对原发感染和继发感染的眼部疾病的病程和体征进行了调查和比较。对初次接种的反应从亚临床感染到严重角膜炎。与结膜划痕术相比，角膜划痕术可导致更频繁、更严重的眼部疾病和中枢神经系统感染的体征。对侧耳皮肤以前的感染大大改善了眼部的后续感染，因此疾病的症状出现得更早，仅限于树突状角膜炎，并有一些间质受累，并且在很大程度上是可逆的。小鼠似乎是研究单纯疱疹病毒眼部感染的合适动物。
In a detailed study of ocular infection by herpes simplex virus (HSV) type 1 in mice, the course and signs of eye disease were investigated and compared in primary and secondary infection using slit-lamp examination, culture of the tear film, and monitoring of the blink reflex. Response to primary inoculation ranged from subclinical infection to severe keratitis. Compared with conjunctival scarification, corneal scarification resulted in more frequent and severe eye disease and signs of CNS infection. Previous infection in the skin of the contralateral ear considerably modified subsequent infection of the eye so that signs of disease occurred earlier, were limited to dendritic keratitis with some stromal involvement, and were largely reversible. The mouse seems to be a suitable animal for studying ocular infection with HSV.
单纯疱疹病毒临床分离株的菌株特异性。
DOI：
10.1001/archopht.1980.01020040310020
发表时间：
1980
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Wander,AH;Centifanto,YM;Kaufman,HE
通讯作者：
Kaufman,HE