SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland.
SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland.
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DOI：
10.1038/s41591-021-01666-2
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发表时间：
2022-03
期刊：
影响因子：
82.9
通讯作者：
Wood R
中科院分区：
文献类型：
--
作者：
Stock SJ;Carruthers J;Calvert C;Denny C;Donaghy J;Goulding A;Hopcroft LEM;Hopkins L;McLaughlin T;Pan J;Shi T;Taylor B;Agrawal U;Auyeung B;Katikireddi SV;McCowan C;Murray J;Simpson CR;Robertson C;Vasileiou E;Sheikh A;Wood R
目前缺乏关于妊娠期COVID-19疫苗接种和SARS-CoV-2感染结果的人群水平数据。我们使用来自全国前瞻性队列的全人群数据，描述了苏格兰孕妇的COVID-19疫苗接种和SARS-CoV-2感染情况。于二零二零年十二月八日至二零二一年十月三十一日期间，苏格兰的COVID-19疫苗接种计划开始，18，457名孕妇接种了25，917次COVID-19疫苗。孕妇的疫苗接种率远低于18至44岁的一般女性人口; 2021年10月分娩的妇女中有32.3%接种了两剂疫苗，而所有妇女的比例为77.4%。在COVID-19诊断后28天内分娩的妇女的扩展围产期死亡率为22.6/1，000例分娩（95% CI 12.9 - 38.5;流行背景率为5.6/1，000例分娩; 80，456例中有452例; 95% CI 5.1 - 6.2）。总体而言，77.4%（4，950人中的3，833人; 95%CI 76.2−78.6），90.9%（748/823; 95% CI 88.7 - 92.7）与入院相关的SARS-CoV-2，98%（102/104; 95%CI 92.5 - 99.7）与重症监护入院相关的SARS-CoV-2以及所有婴儿死亡发生在COVID-19诊断时未接种疫苗的孕妇中。解决孕妇疫苗接种率低的问题，对于在目前的大流行中保护妇女和婴儿的健康至关重要。苏格兰妊娠期COVID-19（COPS）研究的结果显示，与一般人群中的女性相比，孕妇接种疫苗的水平较低，未接种疫苗与妊娠期COVID-19严重并发症（包括围产期死亡率）的风险增加有关。
Population-level data on COVID-19 vaccine uptake in pregnancy and SARS-CoV-2 infection outcomes are lacking. We describe COVID-19 vaccine uptake and SARS-CoV-2 infection in pregnant women in Scotland, using whole-population data from a national, prospective cohort. Between the start of a COVID-19 vaccine program in Scotland, on 8 December 2020 and 31 October 2021, 25,917 COVID-19 vaccinations were given to 18,457 pregnant women. Vaccine coverage was substantially lower in pregnant women than in the general female population of 18−44 years; 32.3% of women giving birth in October 2021 had two doses of vaccine compared to 77.4% in all women. The extended perinatal mortality rate for women who gave birth within 28 d of a COVID-19 diagnosis was 22.6 per 1,000 births (95% CI 12.9−38.5; pandemic background rate 5.6 per 1,000 births; 452 out of 80,456; 95% CI 5.1−6.2). Overall, 77.4% (3,833 out of 4,950; 95% CI 76.2−78.6) of SARS-CoV-2 infections, 90.9% (748 out of 823; 95% CI 88.7−92.7) of SARS-CoV-2 associated with hospital admission and 98% (102 out of 104; 95% CI 92.5−99.7) of SARS-CoV-2 associated with critical care admission, as well as all baby deaths, occurred in pregnant women who were unvaccinated at the time of COVID-19 diagnosis. Addressing low vaccine uptake rates in pregnant women is imperative to protect the health of women and babies in the ongoing pandemic. Findings from the COVID-19 in Pregnancy in Scotland (COPS) study reveals low levels of vaccination uptake by pregnant women compared to women in the general population and that not being vaccinated is associated with increased risk of severe complications of COVID-19 in pregnancy, including perinatal mortality.
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9.8
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6.3
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影响因子：
26.1
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Villar J;Ariff S;Gunier RB;Thiruvengadam R;Rauch S;Kholin A;Roggero P;Prefumo F;do Vale MS;Cardona-Perez JA;Maiz N;Cetin I;Savasi V;Deruelle P;Easter SR;Sichitiu J;Soto Conti CP;Ernawati E;Mhatre M;Teji JS;Liu B;Capelli C;Oberto M;Salazar L;Gravett MG;Cavoretto PI;Nachinab VB;Galadanci H;Oros D;Ayede AI;Sentilhes L;Bako B;Savorani M;Cena H;García-May PK;Etuk S;Casale R;Abd-Elsalam S;Ikenoue S;Aminu MB;Vecciarelli C;Duro EA;Usman MA;John-Akinola Y;Nieto R;Ferrazi E;Bhutta ZA;Langer A;Kennedy SH;Papageorghiou AT
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Papageorghiou AT
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影响因子：
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作者：
Goldshtein, Inbal;Nevo, Daniel;Segal, Yaakov
通讯作者：
Segal, Yaakov
影响因子：
2.9
作者：
Stock SJ;McAllister D;Vasileiou E;Simpson CR;Stagg HR;Agrawal U;McCowan C;Hopkins L;Donaghy J;Ritchie L;Robertson C;Sheikh A;Wood R
通讯作者：
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